A naturally occurring substance produced in the liver, It is one of the four primary components of Ribonucleic acid (RNA). It is a nucleoside meaning that it has a nucleic acid with a pyrimidine base.
it is a powerful substance that helps neurons make form new connections. The main function of this substance is Long-Term Potentiation – the process of memory creation and storage in the brain. Thus, low levels of Uridine in the brain can lead to impaired memory formation.
Moreover, it is a substrate for phospholipids synthesis in the brain, as its receptiveness to other phosphate groups is remarkable.
Also, It works in collaboration with Choline to enhance cognitive function and promote brain health. Studies show that it even might work with omega-3 fatty acids and produce antidepressant effects.
The natural sources of this substance include beer, tomatoes, breast milk, broccoli, sugar cane extract, and yeast. However, you may take Uridine supplements to improve your memory performance, ability to focus, and overall mood significantly.
It can easily cross over the blood-brain barrier with the help of one of two neuro transporters called equilibrate and concentrative. Uridine has several positive effects on the human health, such as improved brain function, pain relief, and protection of heart. It may also help in treating mental disorders.
- Enhances memory, focus, and other cognitive processes.
- Aids in the growth of synapse.
- Increases levels of choline and dopamine in brain.
The basic mode of action of it involves the synthesis of Phosphatidylcholine (PC) in the brain. This chemical is responsible for helping the cells operate and regulate the enzymes in the brain. It also increases the production of neurites, which significantly improves synaptic plasticity and leads to greater encoding and increased storage of memories.
Neurites are basically the projections from the neurons’ body that form synapses with other neurons in different parts of the brain.
You must already know that there are billions of neurons in your brain, which connect with each other to form an intricate network. Some of these neurons form synapses with thousands of other neurons – these connections keep on changing and are not permanent.
Recent research found that upon formation of a new connection for synaptic transmission between two neurons, the process of new memory storage takes place, known as Long-Term Potentiation. Hence, it makes sense how greater levels of Uridine in the brain contributes to better memory formation and retention, and improved cognitive functioning.
In addition to this,
It increases the dopamine level in the brain. Dopamine is an essential neurotransmitter that improves mood and motivation and is involved in the pleasure, arousal, and motivation center of the brain. This neurotransmitter plays an integral role in the executive functioning and enhances your ability to concentrate and pay attention to stimuli.
Not only this, Uridine supplement is also responsible for making Phosphatidylcholine in the brain, which aids in the synthesis of Acetylcholine – a chemical that plays a key role in the brain’s synaptic plasticity and memory. There is a connection between Acetylcholine and some cognitive functions, including reasoning, perception, information processing, memory storage, and performing calculations.
Other potential mechanisms of action of Uridine include increasing the level of CDP-choline through its breakdown, improving the health and function of synapses, and exhibiting cardioprotective properties.
How Uridine improves mood and fights depression and bipolar disorder
Several user reviews imply that Uridine is an effective mood booster supplement – and research supports this claim. Uridine works to upregulate the production and release of dopamine. Dopamine is a neurotransmitter that is commonly called ‘the motivation molecule’ because it is responsible for the feelings of reward and pleasure.
Research shows that Uridine supplementation alleviates depression in both children and adults. Additionally, a popular 2011 study concluded that Uridine supplementation is an effective treatment for depression existing in combination with bipolar disorder.
Moreover, Uridine is known for its property to fight stress, which, in turn, improves mood. Upon supplementation, Uridine transforms into a phospholipid in the brain – and phospholipids counter the negative effects of cortisol.
The dopamine released in the brain upon Uridine supplementation promotes feelings of joy, confidence, and peacefulness. Users suffering from depression tend to find themselves more able to deal with basic stresses of life and find the clarity of mind to address their issues without feeling overwhelmed. Also, the sluggish feelings, procrastination, and lethargy that accompany depression seem to lift.
The Uridine supplement helps greatly with depression symptoms, promotes brain health, and support the regulatory systems to keep mood disorders in check.
The use of these supplements yields a number of beneficial effects. Following are some wonderful benefits and uses of Uridine.
1. Improves memory
Research suggests that long-term use of Uridine can improve memory in humans as well as rats.
One study showed that upon supplementation with Choline, Its helped enhance the verbal and logical memory in humans.
Another study found that this supplement enhanced the learning and memory skills of rats. Also, memory dysfunction caused by damaged hippocampus was greatly reduced.
Yet another study concluded that the levels of dopamine and Acetylcholine were significantly increased due to Uridine-5’-monophosphate exposure in rats.
In addition to this, It may greatly help patients with Alzheimer’s disease by stimulating the formation of synapses and thus, delay the symptoms of Alzheimer’s.
2. Helps reduce pain and inflammation
When patients dealing with carpal tunnel syndrome took a capsule of Uridine monophosphate and folic acid, and vitamin B12 daily, they not only experienced a decrease in their pain score but also reduction in their symptoms and pain intensity.
A study found that oral intake of Uridine triphosphate in combination with vitamin B12 and cytidine resulted in reduced pain in the neck, back, and hips in humans.
Another study conducted on mice revealed that Uridine supplementation helped relieve inflammation and lung fibrosis symptoms by decreasing pro-inflammatory cytokines.
Moreover, testing on human lung cells also showed similar results, confirming the anti-inflammatory effects of Uridine.
3. Helps in brain growth
A combination of Uridine, Choline, and DHA can be effective in displaying a synergistic effect and increasing the number of synapses in the brain.
In one study, it uses leads to improve sleep, promote plasticity, and prevent epilepsy. In sleep-deprived rats, the slow sleep wave increased upon Uridine administration.
Moreover, It activates the P2Y2 receptor, which is vital in neurite outgrowth. This receptor helps in the development and regeneration of neurons, and their protection under inflammatory conditions.
4. Protects the heart
The heart does not receive enough oxygen when there is not enough blood supply to it. In rats, Uridine and Uridine-5’-monophosphate can increase the blood flow and thus, normalize the heart and stabilize its rate.
Its triphosphate can also reduce heart contractions during heart attacks through the activation of P2Y2 receptors.
5. Restores liver growth
One study showed that after a liver transplant in rats, Uridine supplementation helped in restoring the regeneration process of the liver. There was a complete restoration of liver and liver growth cells.
6. Helps with anemia
One study concluded that a combination of Uridine, cytidine, and vitamin B12 was effective in the treatment of anemia. The reduction in pain and other symptoms of the disease was perhaps due to the combined activity of Uridine and cytidine.
7. Helps with HIV-related problems
Research suggests that HIV positive patients have lower levels of Uridine in their blood. The patients usually experience an abnormal loss of fat in different areas of the body.
According to a study, after 24 weeks of Uridine supplementation, the HIV patients noticed an increase in the limb fat.
Since the long-term therapy involved in the treatment of HIV may cause toxicity and other issues in the mitochondria, it may serve as an alternative treatment, as it can prevent the depletion of mitochondria and reverse the toxic effects.
Since it shows synergistic properties with fish oil, krill oil, and other Choline sources, stacking it with Choline sources or omega-3 supplements may improve and cognitive functions.
CDP Choline and Alpha GCP are the common Choline sources used with Uridine.
While it increases the dopamine level in the brain and shows anti-depressant effects, it is often stacked with omega-3 and n-3 fats to amplify the mood-boosting and anti-depressant effects. Krill oil may be the best option amongst the omega-3 sources when it comes to pairing with Uridine because of the presence of astaxanthin and omega-3 phospholipids in it.
One study confirmed that Uridine in combination with other supplements helps enhance the spatial memory of rats over a course of various tests, such as improvement of search strategy and hippocampus-dependent learning.
Thus, an effective way to use this supplement is to stack Uridine with nootropics, such as choline sources or an omega.
Although it is a standalone supplement, it is usually stacked with other nootropics for achieving maximized results.
How much uridine should you take?
The recommended daily dosage of it is 500 mg to 1000 mg. Consider taking two 250 mg dosages in the morning, one in the afternoon, and the last one in the evening.
The Uridine supplement is sold either as a capsule or in powder or tablet form.
Psychonauts within the Nootropic community have experimented with high Uridine monophosphate dosages, up to 2 grams and reported positive mood boosting and uplifting effects minus any serious or even minimal side effect.
How should you take uridine per day?
Therefore, if you want to enjoy the Nootropic and cognitive benefits of this supplement, consider taking a Uridine dosage of 1000 mg to 1500 mg every day.
Many of the foods you eat contain Uridine and even your body produces this substance to some degree. This makes a very safe and well-tolerated supplement. It is safe for every healthy adult to take it – but in the right dosage.
As long as you follow the recommended dosage, you may experience minor Its side effects only. It’s such as fatigue, headaches, nervousness, and some gastrointestinal problems. These are usually a result of taking a high dose and are of very mild severity.
While some evidence suggests that Uridine supplementation may result in low vitamin B12 levels. Its consider taking a B12 or B9 supplement along with your Uridine dosage.
Uridine is an effective nootropic supplement that improves mood, memory, and overall cognitive function. If you are considering benefiting yourself from this supplement and wondering where you should get it from, let us tell you that there are numerous online vendors selling this nootropic supplement.
We recommend that you buy Uridine capsules from any online store that sells high-quality Uridine because it is relatively easy to purchase them online. All you have to do is look for a credible online vendor, place an order online, pay for it, and wait for it to be delivered to your doorstep.
Based on the user reviews of Uridine, it seems to work wonders for the users.
A bipolar patient who used to feel depressed most times of the day started taking Uridine supplement and was surprised to see its beneficial effects. He reported experiencing a significant relief from the symptoms of depression and the best part was that there were No side effects!
Another user reported considerable improvement in overall mood and focus. In addition to this, a user who suffered from sleep problems found this supplement to have a drastic positive impact on the quality of sleep. Uridine supplementation made falling asleep easier and the user felt more refreshed after waking up. Also, this supplement relieved long-lasting muscle and joint pains and improved the problem-solving ability.
All in all, the user reviews of Uridine speak of its effectiveness themselves. If you want to make the absolute most of your brain, Uridine supplement is the answer!
- The incorporation of tritiated uridine in hair germ and dermal papilla during dormancy (telogen) and activation (early anagen).
- Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor.
- Uridine supplementation for the treatment of antiretroviral therapy-associated lipoatrophy: a randomized, double-blind, placebo-controlled trial.
- Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.
- Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally.
- Uridine 5′-diphosphate induces chemokine expression in microglia and astrocytes through activation of the P2Y6 receptor.
- P2Y(6) agonist uridine 5′-diphosphate promotes host defense against bacterial infection via monocyte chemoattractant protein-1-mediated monocytes/macrophages recruitment.
- Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected].
- Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T.
- Oral uridine-5′-monophosphate (UMP) increases brain CDP-choline levels in gerbils.
- Uridine and its nucleotides: biological actions, therapeutic potentials.
- Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells.
- Effect of 5-(phenylselenenyl)acyclouridine, an inhibitor of uridine phosphorylase, on plasma concentration of uridine released from 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine: relevance to uridine rescue in chemotherapy.
- 5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration. Implications for chemotherapy.
- Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.