SAM-e for Depression, Mood and How does it Works? – NOOTRIMENT

SAM-e for Depression, Mood and How does it Works?

S-Adenosyl-L-Methionine Supplements Overview

Whether you’re struggling with depression, anxiety, or osteoarthritis, consider using SAMe supplements to alleviate these conditions and enjoy healthy living.

SAMe (pronounced as Sammy) is the abbreviation for ‘S-Adenosyl-L-Methionine’. It is a synthetic version of S-Adenosyl-L-Methionine (a compound already found in our body). SAMe is now readily available in the form of a dietary supplement.

SAMe Helps for depression and mood

SAMe Helps for depression and mood

This category of supplements has proven to be extremely effective for patients with depression and mood problems. It can be taken orally, through muscular injection or intravenously whichever is suitable for the user. With SAME supplements, you don’t have to live with depression.

Continue reading to learn all that you want to know about SAMe supplements and how to use it to fight back the symptoms and live a beautiful life just like other users.

What Is Same?

Characterized as cognitive enhancers and nootropics, SAMe is a natural and pure anti-depressant supplement. It is made from Methionine and ATP (Adenosine Triphosphate).

Here it is important to understand that SAMe occurs naturally in our body. It is synthesized in the body from Methionine. Majority of the reactions and metabolic pathways that involve SAMe take place throughout our body but it is primarily produced as well as consumed by the liver.

SAMe is a substance that is present in every tissue of our body. And that is exactly why if any changes occur in the levels of SAMe in our body, it directly affects our the cellular functioning. Abnormalities in the availability of SAMe are known to trigger conditions like neurological and mood disorders, and can even result in liver diseases. This is because SAMe is involved in numerous body processes.

For Example SAMe:
  • Plays a crucial role in the immune system,
  • Helps maintain proper cell membranes, and
  • Both produces and breaks down neurotransmitters in the brain like Serotonin, Dopamine and Melatonin

Therefore, SAMe supplements are also orally used to maintain the right levels of S-Adenosyl-L-Methionine in the body, and for the treatment of fibromyalgia, liver problems, dementia, Alzheimer’s disease and depression.


How It Works:

  • It enhances mood & cognitive health.
  • Essentual for dopamine, serotonin & norepinephrine metabolism.
  • It promotes joint comfort & liver health.
Between 400 – 1600 mg per day
Rated Likely Safe

How Does It Work?

SAMe is basically a compound that the liver produces. This compound is used in the entire body in the chemical process that is known as methylation. Methylation is vital for several chemical reactions in the body; and is also among the last steps in the production of dopamine, norepinephrine and serotonin. Since there no food source is high in SAMe levels, the body has to make this compound on its own. This is where the liver comes into action

The liver of our body creates SAMe from the amino acid (protein) Methionine which is found in a variety of food sources. Please note that supplementing with Methionine doesn’t work the way SAMe supplementation works. This is because there are a plethora of steps involved in creating SAMe and many co-factors are required to complete the process successfully such as vitamin B12, folate and B6. In other words, SAMe works best with vitamins B6, B12 and folate.

Although the usage of SAMe in our body is diverse as it is involved in more than 35 biochemical processes that take place in the body, how it works with neurotransmitters is definitely the process of interest.

Firstly, SAMe tends to lower the breakdown process of brain chemicals thereby making them work longer. Furthermore, it speeds up the receptor production that receives the neurotransmitters. Research also suggests that SAMe can make the receptors that already exist more responsive which helps receive messages in a better way. All of these activities lead to increased neurotransmitter levels which help decrease depressive symptoms. Studies show that individual who supplement with SAMe have high levels of dopamine, norepinephrine and serotonin.

Top Interesting Health Benefits of SAMe

Now that we know how it works, let us look at some of the top interesting health benefits of SAMe

1. Fights Depression and Mood Disorders

Did you know that:
  • 10.3 million adults in the US experienced an episode of depression that resulted in the past year.
  • Approximately 50% of the patients with depression also have anxiety disorder.
  • 15% of the adult population is likely to suffer from depression at some point of their life.
SAM-e Stress and Mood Disorder

SAM-e Stress and Mood Disorder

From these statistics, you can imagine how common depression is in the US. It is alarming and sad. It’s true that fighting depression is not easy but it sure is possible. People with major depression may not be able to combat and overcome it only through therapy. In such a situation, clinicians often combine a variety of strategies together like therapy along with the use of supplementary medicine like SAMe for effective results.

The use of SAMe generates therapeutic effects which are similar to antidepressants but they are comparatively toxic free. Besides this, S-Adenosyl-L-Methionine has a faster onset. It is responsible for a variety of transmethylation reactions like the synthesis of the neurotransmitters. Studies show that antidepressants tend to slow down the reuptake of neurotransmitters like serotonin.

However, the intake of SAMe acts as a methylating agent which improves and enhances the synthesis of neurotransmitters in the brain that are linked to our mood like serotonin, monoamines, dopamine and norepinephrine. These neurotransmitters are best known as chemical-pleasure messengers and are associated with positive feelings so they help in fighting depression and other mood disorders like anxiety.

2. Improves Brain Functioning

Studies show that CSF (Cerebrospinal Fluid) SAMe Levels are quite low in patients with major depression and also in patients who have dementia or Alzheimer’s. However, intake of SAMe supplements by mouth, or as an injection, can increase CSF level much needed for improved brain functioning and mood. SAMe slows down the progression of Alzheimer’s while improving spatial memory.

Other Health Benefits Of Same Are:

1. Restores Liver Function

Liver in the body is responsible for controlling SAMe levels. This is the site where synthesis as well as degradation takes place. However, people who have liver diseases like alcoholic and non-alcoholic cirrhosis aren’t able to synthesize SAMe. However, SAMe supplementation can alleviate and treat liver disorders. SAMe prevents liver toxicity and helps normalize the levels of key enzymes in the liver much needed to restore proper liver functioning.

2. Reduces Symptoms of Osteoarthritis

As you may already know that osteoarthritis is a common joint disorder that occurs mostly in elderly aging above 60 years of age. Common symptoms of osteoarthritis include pain in the joints, and stiffness which reduces motion and disrupts the quality of life. The pain and discomfort in some cases can be unbearable. However, the use of SAMe is proven to alleviate these symptoms. Though it has a slower onset, it is still effective.

3. Lowers Fibromyalgia Symptoms

Fibromyalgia is a non-inflammatory but a painful condition that involves muscles. Patients with this condition are also known to suffer from moderate to severe depression. Research however, shows that the usage of SAMe supplements can lower fibromyalgia symptoms like reducing the number of tender and painful points.

How To Take SAMe?

Dosage intake for SAMe predominantly depends on your condition and the purpose for which you’re using it. In other words, it is variable from person to person. This means that there is no recommended SAMe dosage.

Here’s a closer look at a general daily dosage range for SAMe for different conditions:
How much sam-e should I take a day?

In general, the daily dose for SAMe is 400 to 1600mg. However, for those who want to use SAMe supplements to treat liver disorders like Cholestasis, the suggested use is 800 mg to 1600 mg. Likewise, SAMe dosage for depression and other mood disorder treatment is between 200 and 400 mg daily for fifteen to twenty days. The suggested usage of SAMe for the treatment of fibromyalgia is 400mg twice everyday for 6 weeks whilst the right dose for alleviating symptoms of osteoarthritis is between 600 and 1200mg daily.

It is advisable for first time users of SAMe supplements to start with a low dose and gradually increase if needed. This helps the body to better adjust to SAMe supplements without experiencing issues like stomach upset. And because SAMe is essentially a compound/ protein it has no real side effects besides so you can rest assured that it is safe at the dosage level as suggested above.

If you continue to take SAMe, you’ll be able to reach and ensure the right levels of SAMe in the body that are much needed to alleviate symptoms and treat the conditions mentioned above. Remember the right amount of dosage is vital for safety purpose and best results.

Effects of SAMe

Same for Mood Enhancing Pills

There are many effects of SAMe on the body. These include the following:

It donates methyl groups that stimulate DNA cell repair and division, formation of neurotransmitters and control gene transcription.

Other effects include
  • Cell damage repair
  • Cognitive function support,
  • Makes phosphatidylcholine that are present inside the membranes of the cells which facilitates in their communication with other body cells,
  • Stimulates the synthesis of polyamine while increasing transsulfation which further helps catalyze the synthesis of a variety of substances in the body essential for gene expression, neuron regeneration and cellular growth.

Besides these amazing effects of SAMe on the body, evidence suggests that SAMe supplementation may facilitate in playing additional roles in the body such as slowing down the development and growth of cancer tumor cells.

Moreover, SAMe supplementation has also shown significant improvement in the mood of patients suffering from Parkinson’s disease and being treated with L-Dopa. Supplementation is effective because it is believed that L-Dopa may lower the existing levels of SAMe in the body.

Side Effects of SAMe

The best part about SAMe supplements is that SAMe has no severe side effect which makes it very safe to use on a daily basis. Mild side effects may occur but rarely.

But like it’s said prevention is better than cure, similarly you should make sure that you take SAMe supplements cautiously and appropriately according to your condition and purpose of use to avoid possible side effects. Some minor side effects associated with S-Adenosyl-L-Methionine are dry mouth, headache, sweating and dizziness.

It is advisable not to take SAMe supplements at night or in large doses. Also, pregnant & breastfeeding mothers shouldn’t use SAMe. Furthermore, if you have bipolar disorder, then you should first talk to your physician before you supplement with SAMe as it may cause anxiety in some users.

User Review about ‘S-Adenosyl-L-Methionine Supplements

S-Adenosyl-L-Methionine supplements are widely used by people across the US. This supplement is mostly sought by US consumers primarily for its mood enhancing effects and its ability to fight depression. SAMe supplements enjoy a positive response from users.

People who use these supplements acclaim them for their positive results, benefits and effectiveness in treating a variety of health conditions. Users also report these supplements to be safe with no serious side effects.

Many users also state that SAMe is quite effective in overcoming random bouts of depression, keeping mood stable and more importantly depressions symptoms at bay. Users who have experienced great results, continue to use SAME supplements and state that even though they have been using it for years, they haven’t suffered from any kind of long-term side effect.

So, if you haven’t tried SAMe supplements yet because of the fear of side effects or safety purpose, then now you can rest assured that there is absolutely nothing to be worried about as hundreds of thousands of people use it daily to enjoy quality living.

Give SAMe a try to experience the amazing benefits this supplement has to offer. Remember that there is nothing to lose. It’s a supplement that has helped many, and can help you too.


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