Pregnenolone Review: Uses, Benefits, Dosages, and Side Effects – NOOTRIMENT

Pregnenolone Review: Uses, Benefits, Dosages, and Side Effects

Pregnenolone Overview: Enhancing Cognitive Function

Pregnenolone is one of the most essential hormones in the human body. It plays a major role in the synthesis of a number of different chemicals and hormones, including estrogens, androgens, glucocorticoids, and others.

The synthesis of this hormone from cholesterol takes place in the adrenal glands as well as in the liver, brain, skin, testicles, ovaries, and retinas. Since it is a pro-hormone, it leads to the production or synthesis of many other hormones and chemicals. It serves as a precursor to cortisol, progesterone, testosterone, estrogen, and DHEA.

Pregnenolone is a steroidal hormone that offers several health benefits.It is a powerful nootropic that people commonly use to boost their mood, improve focus, and get a massive dose of energy. Being a neuro-hormone, Pregnenolone has neuroprotective properties – and hence, it stimulates the brain and has positive effects on brain functions, such as learning, comprehension, information processing, and memory.

People have used this supplement for relieving stress and enhancing their mood since the 1940s. The best thing about this supplement is that despite the presence of some highly potent metabolites, it exhibits limited androgenic, anabolic, or estrogenic activity and does not produce any significant side effects.

Pregnenolone Supplement Benefits

Pregnenolone Supplement Benefits

Recommended Dosage of Pregnenolone and When to Take Pregnenolone

For a healthy, fit adult who makes sure that he gets proper sleep every night, the recommended dosage of Pregnenolone ranges from 5 mg to 20 mg. However, if the condition is chronic, such as severe inflammation or other major ailments, you may take a higher dose up to 25 mg.

Hormone Supplement
Longevity Longevity
Energy Energy
Memory Memory

How It Works:

  • Enhances various brain functions, like memory and focus.
  • Helps by boosting energy and increasing metabolism.
  • Promotes a balance in hormone secretion.
5 – 50mg per day
Insufficient Research

When to take pregnenolone?

You might want to break the daily dosage into two smaller doses, taking one in the morning and the other in the afternoon. Please note that this supplement may sometimes have stimulating effects so it is better to not use it too late at night.

How much pregnenolone should you take?

While pregnenolone is one of the safest supplements in the nootropics world – researchers have tested a dosage as high as 500 mg per day on humans and surprisingly found no adverse effects, it is still recommended to be cautious and start with the minimum recommended dosage of 5 mg.

Last but certainly not the least, you should consider consulting your doctor before you start taking this supplement to avoid any negative experiences.

What to consider before supplementing Pregnenolone

A simple yet effective method of incorporating Pregnenolone supplement in your regime is to use a high-quality supplement. Do not compromise on the supplement quality if you do not wish to compromise on its benefits.

Pregnenolone supplement aims to support metabolic and adrenal function. And by increasing Pregnenolone availability in the body, you may increase the number of other beneficial hormones including estrogen, progesterone, testosterone, and DHEA.

Typically, users experience the benefits of Pregnenolone over a long period. So, you should not expect an immediate change. There is a reasonable justification for this: Pregnenolone affects the memory, immune function, energy levels, and senses that you cannot notice in a day or two. However, after days of appropriate supplementation, you may notice positive changes in your feelings, thoughts, and overall health.

Pregnenolone Dosage for Adrenal Fatigue

Pregnenolone Dosage for Adrenal Fatigue

Pregnenolone Interactions and Contraindications

Pregnenolone may interact moderately with some hormones. So, you need to be careful with the following combinations.

Interaction with estrogen

Pregnenolone supplementation helps in producing estrogen in the body. Hence, combining it with estrogen pill itself may result in too much estrogen in the body. Some estrogen pills that are likely to interact with Pregnenolone include ethinyl estradiol, conjugated equine estrogens (Premarin), and estradiol.

Interaction with progestin

Progestins are a group of hormones. Taking other hormones pills with Pregnenolone supplement may result in elevated levels of hormones in the body, which may increase the effects and side effects of hormone pills.

Interaction with testosterone

Since the human body converts Pregnenolone into testosterone, combining Pregnenolone supplement with a testosterone pill might increase the risk of testosterone pill side effects.

Furthermore, Pregnenolone may lower the activity of drugs used for treating depression and epilepsy. Also, if you are taking any medications that affect the sex hormones levels, be careful because Pregnenolone increases the natural levels of these hormones.

Please note that children, pregnant women, and breastfeeding mothers should not take this supplement, as not enough clinical data exists to support its use in these populations. Moreover, individuals suffering from uterine, prostate, and breast cancer should also avoid using this supplement. For individuals suffering from prostate cancer, this supplement may worsen the condition by increasing testosterone levels. Similarly, by increasing estrogen levels, it can worsen the condition of people with breast and ovarian cancer.

Pregnenolone has antagonistic effects on the GABA receptors in the central nervous system and may lower the seizure threshold. Therefore, experts do not recommend it to individuals with seizure disorders. In addition to this, uterine fibroids, uterine cancer, and endometriosis are some hormone-sensitive conditions that are contraindicated to Pregnenolone.

Stacking Pregnenolone

Users commonly stack Pregnenolone supplement with DHEA to boost their cognitive function. For more pronounced cognitive benefits, you may stack this supplement with other potent nootropics, such as Phenylpiracetam and Noopept.

How Does Pregnenolone Work in the Body?

Although the mechanism of action of Pregnenolone supplement is not very clear, we do know that it works to produce all the steroid hormones in the human body.

Think of Pregnenolone as the mother of all hormones. Your body utilizes various feedback mechanisms to identify the hormones that it is lacking. If DHEA levels are low in the body, the supplemental Pregnenolone will automatically convert to DHEA. Similarly, if testosterone or estrogen’s supply is short, the nootropic supplement will alter to produce optimum amounts of these hormones. Not only this, even if your body is lacking a combination of hormones, pregnenolone can take care of that too!

Effects and Uses of Pregnenolone

Best Nootropic Stack for Memory

Best Nootropic Stack for Memory

Although your body produces Pregnenolone naturally, as you grow older its production declines. Moreover, some other factors can also interfere in the proper production of this hormone. Considering this, it is easy to see why people take this compound in the form of a dietary supplement to boost its level in their body and enjoy the complimentary benefits.

The oral consumption of this supplement allows it to cross over the blood-brain barrier and reach the central nervous system successfully. There are several biological and chemical processes involved in the working of this supplement in the body.

Being the mother hormone of the body and the productional precursor to some vital hormones, it helps in balancing the levels of other hormones in the body and works wonders for both men and women alike.

In addition to this, once ingested, Pregnenolone focuses on controlling the transmission of messages from neuron to neuron. To be specific, it efficiently regulates the receptors of NMDA, which potentially affect many cognitive functions. The NMDA receptors actually respond to Glutamate – an important neurotransmitter in the brain – and influence the formation of new synapses on the neurons.

The human brain utilizes this process to conduct Long-Term Potentiation, a process through which you encode new memories in the brain. This explains how Pregnenolone is so effective in improving memory function and supporting improved information retention while you learn new things.

9 Remarkable beneficial effects, people use Pregnenolone for a number of reasons, including:
  1. Relieving stress
  2. Sharpening memory
  3. Stimulating the immune system
  4. Fighting fatigue
  5. Slowing down the aging process
  6. Preventing cardiac disease
  7. Promoting detox
  8. Helping with depression and Alzheimer’s disease
  9. Fighting allergies

6 Impressive Benefits of Pregnenolone

Below is a list of some incredible benefits of Pregnenolone supplement.

1. Boosts mental function

Pregnenolone acts as signaling molecules in the brain to stimulate the activity of neurons. It also helps in increasing the length of neurons.

Moreover, this supplement promotes myelination, which ensures the proper functioning of nerves, and enhances the formation of new synapses.

With its neuroprotective properties, it does not only protect the neurons from cell toxicity but also plays a role in neurological recovery.
Thus, this supplement is highly effective in improving cognitive performance, especially learning and memory.

2. Promotes deep sleep

Animal studies suggest that Pregnenolone and its derivative allopregnanolone promote deep sleep.

One study found that high levels of this compound increase REM and slow wave sleep aka deep sleep. Another study concluded that Pregnenolone supplementation enabled the human volunteers to spend more time in deep sleep.

3. Reduces schizophrenia symptoms

This supplement also reduces and treats certain symptoms of schizophrenia. The schizophrenic patients typically contain lower levels of this hormone in their brain. Patients may benefit from Pregnenolone supplementation and experience significant cognitive improvements, better verbal and working memory performance, and improved attention.

4. Enhances mood and reduces depression

Pregnenolone also exhibits mood-stabilizing effects and activates the neurocircuits that control emotions.

In addition to this, this supplement helps with depression. Depressed patients tend to have lower levels of this hormone. By increasing the production and stability of tubules, it promotes neurite growth and hence, fights depression.

5. Relieves anxiety

Since this supplement activates the neurotransmitter GABA, it serves as an anti-anxiety supplement. Studies show that patients with generalized anxiety disorder have a lower concentration of Pregnenolone in their brain. Thus, its supplementation can reduce anxiety and irritability significantly.

6. Balances the immune system

This compound plays a key role in homeostasis. It works by suppressing the immune cells and thus, restores the balance of the immune system.

Research indicates that certain synthetic derivatives of Pregnenolone combat the herpes simplex virus by showing antiviral effects.

Potential Side Effects of Pregnenolone Supplement

There is prominent evidence that Pregnenolone is a safe supplement to use. its use dates back to 1940s and 1950s, which imply its effectiveness and safety.

Several users report tolerating this supplement quite well. However, it is imperative to follow proper dosage pattern and not take a dose higher than the recommended one. In case of an overdose, certain side effects, although temporary and very rare, may arise. You should also consider not using this supplement for extensive periods of time.

Upon taking an inappropriate dosage of this supplement, you may experience some of its effects being reversed. The possible side effects of Pregnenolone include weight gain, disturbed menstrual cycle, increase in blood pressure and glucose levels, increase in heart rate, irritability, and excessive sleepiness.

Pregnenolone to Increase Energy

Pregnenolone to Increase Energy

Pregnenolone Reviews & Where to Buy

Pregnenolone is a potent yet extremely safe supplement with amazing nootropic benefits. Not-so-surprisingly, most of the user reviews of Pregnenolone are positive!

Its users experience significant improvements in their brain functioning, involving learning, memory, and reasoning. According to the user reviews, this supplement works like a charm when it comes to boosting the mood, improving concentration and focus, and providing extra stores of mental energy.

The positive reviews of this supplement are not limited to these benefits. Users also report noticing an overall improvement in their physical health. Pregnenolone also seems to slow down the signs of aging.

This beneficial supplement is quickly gaining popularity and the positive user feedbacks are certainly not coming slow!

From where can you get good a Pregnenolone supplement?

Considering the amazing benefits of Pregnenolone, it is easy to see why it is becoming increasingly popular among the users.
Many vendors sell this dietary supplement online. To make most of its cognitive and health benefits, consider purchasing a high-quality supplement from a trusted vendor. Buying this supplement from an online store rather than going to a pharmacy or medical store will save you a lot of time and energy.

Order your supplement while sitting at home, pay for it online or pay cash on delivery when the deliveryman brings you the magical supplement. This is perhaps the easiest and the most convenient and time and energy-efficient way of getting your hands on Pregnenolone supplement in just a few days.


  1. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation.
  2. Neurosteroids and potential therapeutics: Focus on pregnenolone.
  3. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.
  4. A Randomized, Double-Blind, Placebo-Controlled Trial of Pregnenolone for Bipolar Depression
  5. Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase.
  6. Pregnenolone Can Protect the Brain from Cannabis Intoxication
  7. Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia
  8. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways
  9. Brief Report: An Open-Label Study of the Neurosteroid Pregnenolone in Adults with Autism Spectrum Disorder
  10. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration
  11. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial.
  12. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.
  13. The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens.
  14. Luteinizing hormone inhibits conversion of pregnenolone to progesterone in luteal cells from rats on day 19 of pregnancy.
  15. Pregnenolone, dehydroepiandrosterone, and schizophrenia: alterations and clinical trials.

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