Picamilon Review - Everything You Should Know About Anxiety

Is Picamilon Effective for Anxiety & GABAergic Relaxation

Picamilon Overview: What is Picamilon Used For?

Picamilon, also written as, “pycamilon or “pikamilon, is a synthetic combination of GABA (a neurotransmitter) and niacin (vitamin B3). The chemical structure of picamilon is 4-(pyridine-3-carbonylamino)butanoic acid or nicotinyl-y-aminobutyric acid.

It was first invented in the Soviet Union by the Soviet scientists in the late 1960s or early 1970s. Many people claim that this drug developed to erase Western capitalism with the help of GABAergic mind control. Although there is no proof to support this claim, one thing is sure that picamilon does offer a significant level of mind control.

It has been a common drug prescription in Russia since the 1980s. People use it for stress relief, treatment of depression and migraine and improved brain performance. It is also said to have great anti-aging effects.

Though picamilon is a highly-used drug in Russia, it is illegal in the United States. No medical company can sell it as a prescribed drug. In 2015, the FDA announced that picamilon is a “non-dietary ingredient”. Therefore, brands and manufacturers had to stop its production at once. Despite the ban, there are many companies in the United States that still sell it.

Drugs That Lower Anxiety and Reduce Stress

Drugs That Lower Anxiety and Reduce Stress

How Picamilon Is Supposed to Work?

Niacin – one of the two components of picamilon – is water-soluble in nature. When niacin combines with GABA, it allows GABA to cross the blood-brain barrier through a special niacin analog pathway. Once GABA reaches to the brain, it activates the brain’s GABA receptors where it produces all the beneficial effects like the reduction of stress, expansion of awareness, and improvement of the overall attention span. On the other hand, niacin affects the body by increasing the cerebral blood flow while decreasing the high blood pressure.

Picamilon relaxes the mind as soon as one consumes it. It does so by silencing the background noise in the brain that can disturb your thought process. Due to the constant “mind chatter”, your concentration power starts to deteriorate. You are unable to focus properly which causes confusion and anxiety.

Owing to the presence of niacin precursor, It can improve the overall health of the brain. There is an increase in the blood flow which improves the metabolism of your blood cells. A better blood flow means the removal of toxins from your brain at a quicker rate. An increased blood circulation also means that nutrients like oxygen and glucose reach to the brain faster. This results in an increase in the concentration level and alertness.

Picamilon
Picamilon
Gabaergic Supplement
Mood Mood
Anxiety Anxiety
Sleep Sleep

How It Works:

  • Boosts mood and helps in relaxation.
  • Consists Niacin, GABA and stimulates GABA receptors.
  • Helps in fighting insomnia.
Dosage:
50-400 mg per day.
Safety:
Generally Well Tolerated

Niacin also supports the neuron brain cells. This way, the overall neural health remains in good condition. Moreover, niacin is an important component of vitamin B complex which provides a number of benefits to the nervous system and gastrointestinal system.

Picamilon for Enhanced Cognitive Functions

Drugs That Help with Anxiety

Drugs That Help with Anxiety

Picamilon boosts your brain power, enhances your learning ability and improves your concentration power. These properties help place picamilon in the class of “nootropic chemicals” which possess the ability to enhance cognitive function.

The brain-boosting effects of picamilon seem to work after a few weeks of its consumption. It’s one of those supplements that take time to react in the body. It doesn’t enhance the performance of your brain instantly.

On one hand it increases your concentration span and on the other it decreases feelings of stress and anxiety at the same time. Picamilon possesses the unique ability to energize you and relax you simultaneously. This is the reason why picamilon makes for an excellent supplement for students facing the exams, or employees giving a presentation to a large audience.
Once picamilon reaches your brain, the molecule breaks down by water into GABA and niacin. Niacin helps increasing the blood flow to the brain by enlarging blood vessels. In this way, more blood enters the brain, bringing along fresh oxygen and other nutrients. Your brain cells become more nourished, enhancing your cognitive function in the process.

Its combination of energizing and soothing effects, along with its affordable cost, ready availability, and lack of harmful side-effects, make picamilon supplement an excellent choice for those who want to stay alert and focused but extremely relaxed at the same time!

Is Picamilon Safe?

As long as you consume picamilon in controlled quantities, this stress-relieving supplement is safe. However, the moment you begin consuming it in high doses, picamilon can prove to be quite harmful to your overall health.

It is only then you may suffer from side-effects like dizziness and headache, redness of the skin, nausea, and severe irritation. Thus, it is better to take picamilon in small doses to maintain a good physical and mental health.

7 Potential Health Benefits of Picamilon

1. Reduces Anxiety and Depression

GABA’s main purpose is to stop the neurons from communicating with each other so that the stress level can be brought down. An increased level of GABA can decrease stress and anxiety. This is why when you consume picamilon, your intense anxiety level significantly decreases. What happens is that GABA slows down the firing rate of neurons. It does so by blocking the performance of glutamate – a neurotransmitter that elevates the symptoms of anxiety.

Is Picamilon Effective For Anxiety?

It is important for your brain to have GABA in high levels. Otherwise, you might suffer from anxiety disorders. This is the reason why the intake of picamilon can be so beneficial. Its consumption can instantly increase the level of GABA in your brain.

2. Improves Vision

Numerous reports have shown picamilon’s ability to improve vision. This is true especially for those who have a macular degeneration – a medical condition which results in blurred or no vision, and central choriorentinal dystrophy – a retinal disorder that leads to visual loss.

For instance, in a study, 48 patients with central chorioretinal dystrophy consumed picamilon and eventually noticed an improvement in their vision. They could distinguish between different shapes and colors. Due to picamilon, the patients also observed an enhancement in their peripheral vision.

In another study of 60 patients with macular degeneration, there was an improvement in the eyesight among those patients who took picamilon supplements for three months.

3. Increases the Blood Flow to the Brain

In one study, picamilon helped in increasing the blood flow more than piracetam and vinpocetine – two nootropics that possess the ability to increase the blood flow.

The increased blood flow helps to open the constricted blood vessels in the brain. The opening of these blood vessels helps in treating migraines and severe headache.

4. Protects the Brain

In a study done on rats, picamilon showed an increase in the mitochondrial function in the brain cells of rats with brain trauma. It protected their brains by preventing the cell membrane from further damage.

A decrease in the level of oxidative stress was also seen due to the consumption of picamilon. Thus, it proves that picamilon can protect the brain neurons from getting over-activated. Over-activation of neurons is dangerous. It can result in excitotoxicity (death!).

5. Enhances the Pleasure Response

Some studies report that a high dose of picamilon can elevate the pleasure response. In one study, a low dose of picamilon (1 mg/kg) aided in lowering the stress levels whereas a high dose of picamilon (80-160 mg/kg) increased the pleasure response. This is the reason why medical researchers consider picamilon to be far more effective than papaverine, nialamide, complamin and redergin.

6. Helps with Parkinson’s Disease

Parkinson’s disease adversely affects the nervous system that leads to movement disorders.
People with Parkinson’s disease have a low amount of serotonin and dopamine. A study done on rats showed an increase in the level of dopamine in the brain due to the intake of picamilon.

7. Provides Protection against Nerve Inflammation

Though more research needs to be done in order to prove picamilon’s ability to support neuropathy, one study showed that picamilon reduced the inflammation of the nerves in diabetic rats.

Picamilon Dosage for Anxiety

Picamilon Dosage for Anxiety

Recommended Dosage of Picamilon

It comes in various forms such as powder, pills etc. The doctors recommend taking picamilon in a powder form as it is easier to adjust and monitor when in this form. It has also been observed that picamilon’s effect lasts for up to four hours at a time.

It can provide a number of health benefits if the daily dose range is around 50 to 400 mg. Many experts suggest that one should keep picamilon dosage between 100 to 200 mg. People who are taking picamilon for boosting their energy levels or enhancing their mood should take picamilon within 50 to 100 mg dose.

How much picamilon should you take per day?

On the other hand, those who want to take picamilon for stress relief should consider a high picamilon dosage, somewhere up to 50 to 200 mg daily.

Safety & Side Effects of Picamilon

A low dose of picamilon is usually considered safe. Picamilon has shown far more positive results as compared to anxiolytics. However, if you consume a high dose of picamilon, there are chances for you to suffer from short-term side-effects. You may suffer from a headache, dizziness, nausea, intestinal irritation, and skin flushing.

A high dosage of picamilon can also result in low blood pressure which can be unsafe for those who have low blood pressure already. To avoid suffering from serious side-effects, it is highly recommended to avoid alcohol and other kinds of medicines when on picamilon.

There has been no case of overdose reported, but as a general safety measure, try not to exceed the recommended dosage. You must consult your doctor before using picamilon. If you use any other supplement (s) already, it is better to let your doctor know about it. Only your doctor can tell if it is fine to consume picamilon with other supplements or not.

Where to Buy Picamilon?

Picamilon Benefits

Picamilon Benefits

Many types of drugs simply work as anti-anxiety medication but picamilon is the kind that not only soothes your nerves but makes you more alert and active as well. It has the ability to de-stress you without causing tiredness or drowsiness.

Buying picamilon online isn’t against the law. In fact, buying bulk picamilon is legal in the USA. You can easily purchase good quality picamilon supplements online at a cheaper price. You wouldn’t even need a prescription for its possession.

User can buy it online from various small Nootropic stores. It is not necessary that the most expensive picamilon supplements have the highest quality. The best way to determine the quality of the picamilon supplement is by going through online customer reviews.

You can also determine the quality by seeing if the site uses an independent laboratory or some other testing company to assess their supplements. Another way to determine the credibility of picamilon supplements is to see if the online nootropic stores provide a Certificate of Analysis along with their products. This certifies if the products they deal in are genuine or not.

Picamilon Review

There are many active consumers of picamilon. Some use it for the purpose of improving their memory while some take this supplement for stress and anxiety. Let’s look at some of the customer reviews of picamilon supplements:

“This stuff is amazing! My son’s anxiety levels can get devastating and picamilon has been really good for him. He has been using this supplement for quite some time now and I have seen a remarkable change in him. He doesn’t appear to be as agitated as he used to. He is able to concentrate on his studies as well. Highly recommended!”

“I got really depressed after my father’s death. I just couldn’t concentrate on my work. I didn’t know what to do. One of my friends told me about picamilon supplements. It’s been only a couple of weeks using this product and I feel so much better. I’m able to stay focused all the time.”

“My doctor prescribed me picamilon supplements for my memory. I must say, my memory has improved a lot. I used to forget things quite easily but not anymore!”

References

  1. Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon.
  2. Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data.
  3. State of GABA-benzodiazepine receptor complex in diabetic neuropathy: effect of nicotinamide and nicotinoyl-GABA.
  4. Pathogenetic treatment of central chorioretinal dystrophies with pikamilon.
  5. Effects of pikamilon on the brain water-electrolyte balance and in models of responses to the noise and vibration exposure, and their combination with motion sickness.
  6. The action of emoxipin, lithium oxybutyrate and pikamilon on the blood circulation of the ischemic brain.
  7. Correction of diabetic neuropathies using aldose reductase inhibitors and pikamilon.
  8. Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze.
  9. Validation of the treatment of the neurogenic bladder in children with myelodysplasia using pikamilon.
  10. Results of pikamilon use in the treatment of patients with open-angle glaucoma.
  11. The effect of pikamilon and fenibut on the blood supply of the brain at rest and under gravitational exposures.
  12. Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system.
  13. Determination of picamilon concentration in human plasma by liquid chromatography-tandem mass spectrometry.
  14. Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome.
  15. The effect of hypokinesia on depression and on the central GABA-A receptor complexes in the rat brain.

 

 

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