Phenylpiracetam: Benefits, Uses, Side Effects, and Dosage Level – NOOTRIMENT

Phenylpiracetam: Benefits, Uses, Side Effects, and Dosage Level

Overview Of Phenylpiracetam: How To Improve Cognitive Function

Phenylpiracetam is one of the most potent nootropics. It is about 50-60 times more powerful than Piracetam.

People use it as a prescription and an over-the-counter drug to relieve their stress, recover from a stroke, and treat certain diseases that affect the blood flow to the brain.

This drug helps improve cognitive functions in patients with some forms of impairment. In addition to this, it also works great with depression and anxiety symptoms. It has psychostimulatory effects and helps in enhancing physical performance.



Phenylpiracetam is effective in boosting brainpower, motivation level, overall energy, and health. Athletes take this supplement to enhance their performance. People generally use it to improve focus, alertness, mental attention, balance their mood, and increase their productivity.

What Is Phenylpiracetam?

A nootropic belonging to the Racetam family, Phenylpiracetam has significant positive effects on cognition, energy metabolism, stress control, and behavior.

You may find it under the brand names Carphedon and Phenotropil.

A psychopharmacologist, Valentina Ivanovna Akhapkina, supervised the development of this amazing supplement at the Institute of Biomedical Problems in the Russian Academy of Sciences. The first publication of the descriptions of Phenylpiracetam in Russia leads back to 1983.

The beneficial effects of this supplement on memory, learning, depression,etc. are even greater than the first ever nootropic drug called Piracetam.

Contrary to common psychoactive drugs like Adderall, Phenylpiracetam does not produce as many side effects. Even the ones that are produced are much safer and minor.

Nootropic Supplement
Memory Memory
Attention Attention
Focus Focus

How It Works:

  • Helps in learning process and memory
  • Heightens alertness and attention
  • Enhances concentration and productivity
Between 100 – 300 mg per day
Some Reported Side Effects

What Are The Main Purpose Of Using Phenylpiracetam

People use Phenylpiracetam for both medical and non-medical purposes.

Medical Uses:

When it comes to the medical uses of this supplement, it tends to help with:

  • Cognitive impairment
  • Psychoorganic syndrome
  • Encephalopathy
  • Shift-work sleep disorder
  • Prophylaxis for stress
  • Obesity and weight loss
  • Anxiety, depression, and asthenia after stroke
  • Epilepsy and other seizure disorders
  • Traumatic brain injury
  • Disorders of the Central Nervous System
  • Schizophrenia
  • Alcoholism
  • Neurotic conditions with symptoms, such as fatigue, excessive weakness, and memory loss

Non-medical uses

The non-medical uses of Phenylpiracetam include:

  • Cognitive enhancement
  • Immune boosting
  • Mood-boosting
  • Prevents stress
  • Improves focus and motivation
  • Enhances athletic performance and provides pre-workout energy
  • Improves studying and academic performance
  • Nootropic

8 Impressive Benefits Of Phenylpiracetam

Following are the benefits of taking Phenylpiracetam supplement, whether in capsule or powder form.

1. Enhances Cognitive Functioning

Phenylpiracetam improves cognitive performance and makes demanding tasks easier to perform. Patients with brain dysfunction may use it to improve their cognitive functions.

2. Helps With Depression

This supplement exhibits mood-boosting effects and thus, helps in the treatment of depression. It lifts the overall mood, reduces anxiety and discomfort, and makes execution of daily activities easy.

3. Increases Energy Levels

It promotes higher energy levels without causing over excitation that many stimulant drugs do. Taking appropriate dosage is the key to enhance wakefulness and improve energy levels.

4. Promotes Vision Health

Given the neuroprotective properties of this supplement, a study found that it could slow down or reduce the vision loss among glaucoma patients.

5. Aids In Weight Loss

The anorexic effects of Phenylpiracetam can promote reduced food intake. Hence, it serves as an effective treatment for obesity in patients with metabolic syndrome.

6. Helps With Epilepsy And Seizures

The anti-convulsant mechanisms of this supplement may help in the management of epilepsy and other seizure disorders. It improves communication between the brain cells and thus, acts as an anti-epileptic drug.

7. Enhances Athletic Performance

Athletes and fitness freaks usually take this supplement before a workout to enhance their performance, improve energy, pain tolerance, endurance, and reflex control.

8. Improves Memory

Phenylpiracetam greatly helps people with an age-related cognitive decline, Alzheimer’s disease, and other conditions affecting memory.

Suggested Use Of PhenylPiracetam



Users, especially athletes, students, and working people commonly use Phenylpiracetam supplement to increase their energy levels, productivity, and performance. It keeps the users awake and alert as well as boosts their motivation and mental energy while doing demanding tasks.

Another suggested use of Phenylpiracetam supplement involves using it to overcome their feelings of nervousness and stress.
Moreover, those who dream of having a fit, lean body that too in a short period of time, stack it with their pre-workout supplements to increase their stamina, improve neuromotor impulses, and workout at a greater intensity.

One important thing to note here is that this supplement has a fast tolerance build-up, which means that you are likely to see its effects diminishing after using it consecutively for several days. Therefore, you should consider using it only on certain occasions or cycling it on and off.

2 Major Types Of Phenylpiracetam

Below are the two types of Phenylpiracetam:

1. Methylphenylpiracetam

It is a methylated analog of Phenylpiracetam – it has an extra methyl group in its structure.

Research suggests that the E1R stereoisomer of methylphenylpiracetam has no side effects on the locomotor activity and has greater cognitive enhancing properties than (R)-phenylpiracetam.

This substance is a positive allosteric modulator of the sigma-1 receptor. It restores cholinergic neurotransmission and thus, prevents cognitive impairment induced by scopolamine.

2. P-Cl-Phenylpiracetam

Another derivative of Phenylpiracetam, P-Cl-Phenylpiracetam is about 5 to 10 times more potent than its parent is.

It is also known as 1-pyrrolidineacetamide and has a chemical structure of 2-(2-oxo-4-(4-chlorophenyl)-pyrrolidine-1-yl) acetamide.
One animal study found it to have greater anti-depressant and anxiolytic effects than Phenylpiracetam itself.

How Does It Work?

Although the mechanisms of action of Phenylpiracetam are not very clear, the cognitive enhancer seems to work in the following ways:

  • It increases the number of dopamine, serotonin, and GABA receptors in the brain, and thus helps in improving mood and reducing anxiety.
  • It inhibits the activity of dopamine transporters and consequently increases the level of dopamine in the brain, producing a positive effect on mood and motivation.
  • It binds to and increases the number of nicotinic acetylcholine and NMDA receptors in the brain that promote the process of learning and memory formation.
  • It increases the level of a protein, called BDNF, that helps ensure the survival of brain cells in the hippocampus – the memory center of the brain.
  • It helps with seizures by selectively reducing the activity of brain cells – the motor cortical neurons – that are responsible for controlling movements.
  • It increases the alpha/beta waves in the brain which help in overall mental functions, including calmness, focus, alertness, and learning.

Effects Of Phenylpiracetam

The use of Phenylpiracetam yields several positive effects. Some of them are as follows:

  • It improves physical performance
  • It boosts alertness and improves focus
  • It increases the learning capacity
  • It promotes memory formation, retention, and recall
  • It elevates mood and keeps the users energized

How To Take Phenylpiracetam

Buy Phenylpiracetam Supplements

Phenylpiracetam Supplements

The typical recommended dosage of Phenylpiracetam is about 100 mg to200 mg. Consider taking this dose two or three times per day, making a daily total of 200-600 mg.

Since this drug is more powerful than Piracetam, it is recommended to start off with a smaller dose and gradually increase it if need be.
Even after 3-5 hours of taking this supplement, half of the drug remains in the bloodstream.

Moreover, it does not take much longer to develop tolerance to this drug and therefore, you should only use it as a periodic enhancer and not a daily supplement.

Contraindications Of Phenylpiracetam

As in the case of the majority of smart drugs, there are no significant known drug interactions between Phenylpiracetam and other supplements or any prescription medications.

Nevertheless, it is always advisable to be careful and talk to your doctor or a medical health professional before you begin Phenylpiracetam supplementation, especially if you are taking any prescription medication. Also, it is better to check all the ingredients to make sure you are not allergic to any.

There are chances that Phenylpiracetam may increase the effects of drugs that stimulate the central nervous system, neuroprotective drugs, and antidepressants. When it comes to contraindications for Phenylpiracetam, you should be aware of hypersensitivity to the drug.

Patients who struggle with severe hypertension or advanced atherosclerosis and those with severe organic liver and kidney failure must be cautious with Phenylpiracetam supplementation.

Additionally, people with a previous history of panic attacks, acute psychotic state with psychomotor agitation that possibly worsens anxiety, panic, delirium, and hallucinations, and patients who are prone to allergic reactions to nootropics pyrrolidone groups should take precautions and not begin a Phenylpiracetam regimen without getting a green signal from their doctor or physician.

Moreover, if you are pregnant or breastfeeding, you should avoid taking this supplement to prevent any possible detrimental side effect because there is not enough clinical trial data to know for sure if it is safe.

Is Phenylpiracetam Tolerance Possible?

Tolerance occurs when you continually use a substance at the same dosage so that its effects become less pronounced. And then you need to take a higher dose to achieve the same effects again.

The user reviews of Phenylpiracetam indicate the potential to develop tolerance to the drug’s effects. However, there is some medical literature that suggests otherwise so it is a bit of a controversy. But still, you should avoid developing a tolerance because taking high doses of Phenylpiracetam will increase the risk of side effects. In addition to this, you are likely to experience withdrawal symptoms upon discontinuing the substance.

If you feel like Phenylpiracetam is losing its effectiveness after a few days of starting its use, you should consider beginning an on and off cycle of this nootropic to minimize the possibility of tolerance. You should not take this substance every day for an extended period of time unless your doctor advises you to.

While researchers have used dosage protocols as high as 400 mg of Phenylpiracetam every day for about a year, such high dosage is typically for people with some kind of cognitive dysfunction, traumatic brain injury, or cerebral ischemia.

The best way to take Phenylpiracetam in the right dosage is to identify what your goals and reasons are for using it in the first place. Some nootropic users take it only in certain situations, such as before appearing for a test at school or to help perform well on an important project or presentation at work. If that seems to work for you too, you do not need to go overboard with its supplementation to prevent tolerance. It is better to talk with your doctor or a medical health professional first and discuss your health condition to make sure you know the right dosage for you. It is also important to be proactive and follow an irregular cycle of Phenylpiracetam intake.

Six Common Side Effects Of Phenylpiracetam

Recommended Dosage of Phenylpiracetam for Anxiety

Phenylpiracetam for Depression

Although Phenylpiracetam is quite a safe and well-tolerated drug when taken in appropriate doses, as reported by users, there are chances of some minor Phenylpiracetam side effects.

An overdose may cause temporary adverse effects, such as:

  • Headaches
  • Excitation
  • Anxiety
  • Irritability
  • Restlessness
  • Nausea

Some users experience insomnia and disturbed sleep if they take a dose of this drug late at night. Hence, it is best to take this supplement in the morning or early in the afternoon to minimize disruption in the sleep pattern.

It is essential to consult with your doctor before taking this supplement. There is no evidence of addiction and withdrawal symptoms of this drug but users may develop a tolerance to its positive effects over time.

Where To Buy Online

While pharmacies in Russia and some Eastern European countries sell Phenylpiracetam as a prescription and over-the-counter medication, those in the United States, Canada, Australia, and the United Kingdom do not yet regulate it as a prescription drug. However, it is legal to buy, possess, and use the drug.

There are a number of vendors selling this supplement online. While buying online, make sure the vendor is reputable and has a history of providing premium quality products. Try to find a vendor providing a COA (Certificate of Authenticity.) You would be satisfied knowing that the product you are buying is authentic and does not contain any impurities or contaminants.


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