You will be surprised with the remedies nature has provided in the form of fruits and vegetables. Inositol is one such substance that is found naturally in cantaloupe, citrus fruits and fiber-rich foods like beans, brown rice, corn, and sesame seeds. It is available widely in the form of supplements that you can consume as a remedy for psychological conditions like anxiety and depression.
Derived from the Greek word “inos,” Inositol was first extracted by Scherrer in 1850. The nutritional benefits of Inositol were explored almost a hundred years later, in the 1940s. From storing and metabolizing amino acids to strengthening the immune system of your body, It is widely used in addressing several medical concerns.
Inositol is currently being studied for health conditions like Alzheimer’s, autism and schizophrenia. Escalating the presence of Inositol in the cerebrospinal fluid and plasma helps to balance the chemicals in your body and attain relief from mental health disorders. Besides this, It is also widely used as a substitute for antidepressants and helps in controlling health issues like panic disorders and binge eating.
Inositol is a naturally occurring compound that is commonly known as Vitamin B8. It is widely used for the treatment of a wide range of mental health conditions. It is found in plants and animals. The chemical structure of Inositol entails nine stereoisomers. This is why it is commonly referred to as myo- Inositol.
It is not a true a vitamin. It is essentially a carbohydrate that is sweet and is considered a mood-enhancing nutrient. Its chemical formula is similar to that of glucose, i.e., C6H12O6. This makes it a form of natural sugar that is quick to break down. It facilitates the process of building cell membranes. Serving as a secondary messenger in the central nervous system, Inositol is also known to increase the impact of neurotransmitters in the brain. This results in casting mood-boosting effects in people.
It was once considered a part of the B complex vitamins family and got referred to as vitamin B8. But, as the research progressed, it was discovered that the human body could develop Inositol on its own. Therefore, it is no longer considered a true vitamin.
- Helps in regulating mood and nerve signals
- Helps regulating liver and brain health, weight loss
- Helps in conditions, like PCOS insulin sensitivity and fertility
Choline are both highly effective medicine substance that are quite similar to vitamins is properties. Both of these drugs have different uses and effects on the body.
Inositol is mostly popular patients that are suffering from diabetes especially during pregnancy. This type of disease is also called gestational diabetes and can also occur to women who aren’t diabetic at all. Experts recommend patients to take myo-inositol which is specific type of inositol. This medicine is known to suppress the growing diabetes by 60 to 90 per cent.
Other uses of inositol are to cure the metabolic syndrome and panic disorder. Inositol is known for increasing the resistance of the insulin and also improves the cholesterol level.
When it comes to properties then both inositol and choline might seem like similar drugs but their uses tells different story. Choline is most popularly used to cure liver disease that is usually caused by excessive vein feeding. Choline is also know to effectively lessen the symptoms of asthma in many users. It is also known for reducing the use of bronchodilators among the asthma patients. Choline is also known for reducing the risk of the neural tube defect that can sometimes occur during the type of conception.
It is a better-known fact that both choline and inositol are mood enhancing supplements with similar properties like a vitamin B. despite being almost similar supplements both inositol and choline are extracted from different sources and also have a significantly different mechanism of action once they enter the bloodstream inside the body.
Inositol is mainly known as go to medicine when it comes to treating anxiety. But to understand how it does it we need to look at its mechanism of action. According to the “Journal of Clinical Psychology” of 1995, both depression and anxiety are caused by decreased levels compound named ‘serotonin’. Serotonin normally exist inside the blood platelets which are responsible to constrict the blood vessels. Inositol is one of the most popular choices of solution that experts recommend to the people suffering from anxiety and depression. What inositol does is that it increases the level of serotonin by easing the constriction on the blood vessels by the blood platelets.
Choline is known to be a good transporter of fat throughout the network of blood vessels. It properly transfers all the necessary fats from the liver to different areas of the body where they are used to create cell membranes and DNA.
The mechanism of action for Inositol is not completely known. There is still a lot of research that needs to be done to understand the working of Inositol in the human body. However, it is scientifically thought to be involved in various cellular processes as the structural basis in the eukaryotic cells. It is found playing an integral role in the synthesis of neurotransmitters, serving as a precursor to the phosphatidylinositol cycle.
It is also involved in the insulin resistance. Insulin deficiency is associated with insufficiency of Inositol, as a shortage of the later induces deficit in the glucose uptake. Inositol serves as a direct messenger of the insulin signaling and enhances the absorption of glucose. This mechanism makes this precise vitamin B8 beneficial in the treatment of diabetes, metabolic syndrome, and weight loss.
Inositol is also reported to increase the lower-phosphate levels in the human body. This affects the regulation and growth of malignant cells, making Inositol beneficial in reducing cancer-related risks.
Inositol is an isomer of glucose and is naturally found in the brain in high concentrations. It is presumed to have a substantial impact on the action of dopamine and norepinephrine among other neurotransmitters. As per the available research, It is reported to have positive outcomes for treating conditions like depression, ADHD, sleep disorders, hair-related problems and weight loss.
1. Promotes Sleep
It is found effectual in regulating comfortable and sound sleep among users. The primary reason behind sleep disorders and inability to get proper sleep at night is over-thinking. Your mind is often full of stress and is flooding with worries and thoughts when you lay down to sleep. This keeps your mind from relaxing and letting your body slip into a smooth sleep mode.
This active state of your mind is linked to the serotonin levels working in your brain. Low levels of serotonin lead towards an inability to sleep. When you consume Inositol supplements, they work well with serotonin to ensure a peaceful night’s sleep.
2. How to Help Anxiety
It is found to have substantial interaction with the central nervous system. The high level of Inositol present in the brain facilitates communication between the brain cells. Neurotransmitters such as dopamine, GABA, acetylcholine, and serotonin rely on Inositol to propagate messages. This makes integral role player in your mental health.
Its sufficient presence in the brain ensures that there is healthy communication between the cells and the bodily functions are regulated effectively. Inositol is found effectual for treating mental conditions related to anxiety-like depression, panic disorder, and obsessive-compulsive disorder. It is deemed as a natural anti-anxiety remedy and has proven to be effectual in reducing panic and improving depression scores.
If you are suffering from anxiety or depression, it is recommended that you increase citrus fruits, cantaloupe, and other fiber food products in your meal, and consider consuming Inositol supplements. Your anxiety is most probably triggered due to the low serotonin levels in your brain. Since Inositol helps in regulating serotonin levels, it can be highly effectual for you.
3. Hair Care And Growth
If you are facing hair fall or feel itchiness in your scalp, this indicates that you may be suffering from Inositol deficiency. Hair loss usually occurs due to the high levels of androgens circulating in your body. These androgens activate the dickkopf -1 gene that produces DKK-1 protein. This precise protein is lethal for the papilla cells, the cells responsible for hair follicles’ nourishment.
Hence, there is increased hair fall. Consuming this supplements is effectual for this condition because it reportedly reduces the levels of androgens in the body and lowers the activity of dickkopf -1 gene. This chain of events creates a productive environment for the hair growth. You can also combine Inositol supplements with choline to reverse the process of hair loss.
4. Improves Weight Loss
This supplements that have proven effective for weight loss. This efficiency is credited to Inositol’s ability to impact the hormones and serve as a secondary messenger for the cells in your body. Alongside weight loss, it also helps in how to lose weight with PCOS and mood disorders. This is one reason why this supplement is relatively more common among women.
It reduces weight by contributing to the treatment of leptin resistance. Leptin is a fat regulator. Its malfunctioning leads the person towards conditions like obesity. Inositol helps in reducing the leptin levels and controls the release of insulin in your body. Both these activities contribute to improving weight loss.
Inositol and choline are both very advantageous drugs. They possess similar major features but acts with a different approach to the body. There are many other alternative drugs in the market that might offer the same results as choline and inositol. But these two drugs will always remain the top choices due to their almost no side effects even after mildly excessive consumption.
If you are suffering from depression or anxiety or you happen to know someone who is going through it then the first choice to treat them is by using inositol. Inositol is almost a guaranteed solution to the problems like anxiety and depression as it gives you instant results. If you check reviews of this drug from previous users than you will know how inositol and choline really stacks for better results. You can expect similar successful results from people who use choline for mood enhancing and to cure many other problems.
Inositol Dosage Levels are,
There are various dosage levels of Inositol presented through scientific research. It is deduced that the dosage consideration of the supplement hugely depends on the condition for which it is consumed for. Inositol is beneficial to get your physician’s advice on the Inositol dosage prior to the consumption.
It is available in forms of capsule and powder. If you are considering a small dose, capsules can be a beneficial option for you. This is effectual for treating conditions like PCOS. However, if your condition requires you to take a larger dose of the supplement, you should consider taking it in a powdered form.
The dosage level of Inositol supplements ranges from as low as 200 milligrams to as high as 18 grams per day. If you are planning to use Inositol for PCOS, doses between 200-4000 milligrams per day are effectual. You can take it before breakfast. Consuming it with D-chiro-Inositol makes the effect stronger.
Inositol dosage level for Anxiety is recommended between 12 and 18 grams a day.
There is no concrete research on the side effects of this supplements. However, there are some concerns shown
that it diminishes the ability of the body to absorb minerals like zinc and calcium. it is considered safe to use for adults. Like other nootropic supplements, there can be some mild side effects like:
- Stomach/ abdominal pain
You can use it orally during pregnancy. Though there is no evidence that it is unsafe when breastfeeding, as per precautionary measures, it is better that you avoid it to make sure of safety. People with bipolar disorder are advised to take this supplements in limited quantity. Taking excessive dosage in such condition may lead towards psychosis.
It is a relatively harmless supplement. No clinical evidence is available to report any adverse reactions caused due to its consumption.
- Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial.
- Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
- Efficacy of IP6 + inositol in the treatment of breast cancer patients receiving chemotherapy: prospective, randomized, pilot clinical study.
- Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer.
- In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor.
- Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions.
- Does ovary need D-chiro-inositol?
- Bye-bye chiro-inositol – myo-inositol: true progress in the treatment of polycystic ovary syndrome and ovulation induction.
- The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome.
- The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial.
- Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome.
- A phase I study of myo-inositol for lung cancer chemoprevention.
- Studies of chemopreventive effects of myo-inositol on benzo[a]pyrene-induced neoplasia of the lung and forestomach of female A/J mice.
- Scyllo-inositol depletion in hepatic encephalopathy.
- Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study.