DMAE (Dimethylaminoethanol), also referred to as “Deanol”, is an organic choline molecule produced in the human brain. It is similar to Choline but has a different structure with one less methyl group. It is a nootropic supplement known to have beneficial effects on brain health that improve cognitive abilities.
Also found in anchovies and salmon, DMAE drugs that increase brain power like improve memory and slow the aging process by controlling cholinergic deficit. This is the reason why it is used to make specific drugs that are supposed to help patients who show symptoms of Alzheimer’s. Many people use DMAE supplements instead of Choline Bitartrate. It is more potent and it increases the levels of acetylcholine neurotransmitter.
The constituents of this compound have a beneficial impact on cognitive abilities. Focus, attention, mental processing and execution are all improved. It attaches itself to neurons and protects the cells from the harmful effects of oxidation. This antioxidant quality of DMAE also sustains metabolic processes though methyl donation.
DMAE supplements slow down age-associated cognitive decline by reducing the build-up of aging pigments. Similarly, DMAE used in creams and ointments is used to tighten sagging skin, treat aging spots and improve its overall health.
To understand it simple words, DMAE is basically the cholinergic molecule that lacks one of the methyl group when it comes to chemical properties.
One of many abilities of DMAE is anti-aging affect which it causes by reducing the age pigmentation in a human body. This age pigmentation is also by the name of beta-amyloid. DMAE can be found in many pharmaceutical products such as Centrophenoxine and Lucidril. These products are usually produced for elderly patients. However, people tend to use it for cosmetic purposes as well.
- Helps in focusing and concentrating
- Boosts acetylcholine and enhances memory
- Fights aging and has neuroprotective properties
One of the main reasons that doctors recommend DMAE to elderly patients is that it improves their cognitive functions. The human body loses its cognitive functions slowly as it ages so it requires a boost in order to function which is exactly what DMAE is for. DMAE is also known for boosting memory skills by increasing the level of acetylcholine. Besides enhancing all these body functions, DMAE also protects several cells and neurons from oxidation which has certain harmful effects. Another big advantage of DMAE includes the sustenance of metabolism.
DMAE can usually be found in the form of medicated body and face creams which are mostly used to tone and tighten the skin.
DMAE has two methyl molecules attached to its nitrogen molecule. That gives it the ability to cross the blood-brain barrier readily. This is the main reason why DMAE is preferred over other supplements. It has better transportation abilities than other Choline forms. The compound sustains various processes in the human body. It creates various effects including the following:
1- Cognitive Effects
As DMAE is known as a smart drug, it has many impacts on the cognitive and mental abilities once it reaches the brain. After ingestion, the molecules of the compound cross the blood-brain barrier. When the DMAE molecule reaches the brain, it is methylated and converts the choline into Acetylcholine, which is a neurotransmitter.
This compound is crucial for the brain’s cognitive function as it improves memory formation and learning. It is essential for the brain as it performs the pivotal function of forming new connections between neurons. It enhances the process of impulse transmission. Optimizing brain activity, DMAE helps the neurons enhance reasoning, focus, reasoning, logic learning.
Besides that, DMAE synthesizes Centrophenoxine. It is seen to have the potential to repair brain damage in Alzheimer’s patients. Also, people who have suffered strokes. Acetylcholine Neurotransmitter attaches to neuron membranes. It causes a membrane depolarization effect that improves sustaining memories.
2- Antioxidant Effects
DMAE molecules also have the potential to have antioxidant effects on the body, especially in the brain. According to studies, DMAE is known to attach itself to phospholipids present in the membranes of receptors or neurons in the brain. This activates DMAE’s ability to protect the neurons from the harmful effects caused by certain variations of oxidation.
In another study, it was found to be a free radical scavenger in site-specific areas besides the brain. It stabilizes cells membranes and improves the neuronal and cellular health by removing free radicals near cells.
3- Anti-Aging Effects
Taken orally or applied on the skin, DMAE has potent abilities to have anti-aging benefits for the human body. By embedding into cell membranes, DMAE increases the permeability and fluidity of the cell. This improves the cell’s health as DMAE ensures that harmful compounds are kept out, and healthy nutrients are absorbed in. Since cell fluidity decreases with age, taking DMAE supplements also prevents the signs of aging.
The combination of DMAE’s antioxidant effects helps improve skin health as it removes free radicals. This contributes to the structural support of the cells, reducing the chances of discoloration, wrinkles, tightens the skin and prevents rapid muscular sagging. On the other hand, the effects of DMAE prevent the cognitive decline of the brain caused by aging.
The effects that DMAE has on the human body are due to its supplements having numerous benefits. These benefits are mostly associated with the DMAE supplements’ ability to synthesize acetylcholine and embed itself into neuronal cell membranes. The most prominent benefits of DMAE include its capability of reducing the level of stress and anxiety and improving cognitive functioning among others.
1- Improves Memory and Brain Function
As discussed previously, DMAE can improve memory by increasing the levels of acetylcholine in the brain. This enhances the brain’s ability to remember, recall and learn new memories better. The neurotransmitter also helps the neurons’ synapses by increasing their ability to transfer messages from the brain to the entire body more efficiently. It lengthens the attention span, concentration, and focus, suggesting DMAE’s ability to be helpful for people suffering from a cholinergic deficit and attention-related ailments.
2- Reduces Anxiety and Stress
Research studying the effects of DMAE on students during exams showed the compound to have anti-stress effects on the subjects. With acetylcholine levels increased in the neurons, their memory and focus increased. This reciprocated by decreasing the levels of stress and calming the students down.
3- Anti-aging benefits
Besides improving memory and other cognitive functions an aging brain, DMAE is reported to have anti-aging benefits for the skin as well. The antioxidant properties provide numerous benefits for the skin including firming it. It aids your skin to look more youthful by reducing blemishes, inflammation wrinkles and other signs of aging by preventing the production of arachidonic acid.
4- Increases Creativity
An interesting benefit of DMAE is using it to induce lucid dreaming. As the neurotransmitter improves the brain’s ability to focus, it can help control your actions even while dreaming. DMAE users who were able to lucid dream successfully noted they were able to be more creative and engage in associative thinking. It also improved their ability to concentrate effectively during activities that required intense focus.
While the research on DMAE has promising results, it is limited and needs further clinical studies to solidify its numerous benefits for the brain.
While using DMAE supplements has its benefits, in some instances and exceptional situations, it causes some contradictory effects. Also, DMAE is rated Possibly Safe by the Natural Medicines database, so there is some caution required before taking it in specific instances like:
1. Dmae during Pregnancy
The research for DMAE’s effects on pregnancy is limited. This is why pregnant and breastfeeding women should avoid taking it to be on the safe side.
2. Bipolar Disorder
People with severe depression, bipolar disorder, or other seizure-related diseases should avoid DMAE as it might worsen their symptoms.
Besides that, DMAE might interfere with certain medications including Acetylcholinesterase inhibitors like Aricept, Cognex, Razadyne, and Exelon. Take doctor’s prescription before using DMAE if you’re on any cholinergic or anticholinergic medications.
The most common side effects of DMAE include the following:
- Gastrointestinal issues
- High blood pressure
- Moderate depression symptoms
- And sometimes, a strange body odor
Taking DMAE for ADHD
In 1970s Europe, Riker Laboratories used to sell DMAE under the trade name Deaner as a prescription pharmaceutical.
Intrigued by its potential to help children with ADHD, Deaner was investigated thoroughly by numerous researchers. The results found the drug to be beneficial for improving behavioral conditions and hyperactivity in children. But when studied for its effects for ADHD, the results were mixed.
A 1976 double-blind placebo study examined the impact of DMAE in hyperactive children. While these children were not diagnosed with ADHD at the time, they would possibly qualify under modern guidelines. Participants were given 300mg DMAE in the morning and 200mg at lunchtime for twelve weeks. Compared to the placebo group, the results showed behavioral improvement in the test group.
But even with the results from this study along with two others, the research remained inconclusive. Since then, the research on this area is limited.DMAE is not approved by the FDA as a treatment for ADHD, learning disabilities, cognitive impairment disorders or other behavioral and medical conditions.
How much dmae should take?
It is used for many purposes including the benefits discussed earlier. This means that the dosage for every purpose needs to be different and will vary depending on various factors. That is why it is recommended that you talk to a doctor for the right prescription.
While high doses of 750 mg are prescribed in certain cases, most people are recommended a starting dose for 150 mg. This might vary depending on desired outcomes and patient’s health history. But generally, it is better, to begin with, the lowest effective dose to see how it affects your body and increase it when you’re sure of its impact.
Anecdotal user reports and research label DMAE as a nootropic supplement. “It is used by people looking for ways to promote brain function and memory“. It has proven to have various benefits for the human body as it improves cognitive functioning of the brain. DMAE also increases concentration and overall improves neurons’ cellular health. It is a source of choline and encourages the production of Acetylcholine, both of which contribute to enhanced synaptic plasticity.
Users report most of these benefits through testimonials. And while they show promising results, there is a need for more research to study its effectiveness as a dietary supplement.
DMAE products can normally be found at any good pharmacy store near you. The first thing you need to do is grab a prescription from your doctor in order to get the correct type of product. The next thing is to locate a good pharmacy store that can provide you with the desired product. But if you do not have the time, or simply just don’t want to go out and visit a pharmacy then there is always the internet to help you out.
We are living in a modern age where e-commerce has revolutionized the shopping experience. Besides all other necessities of life, you can now also buy medicinal products online as well. These pharmaceuticals products also include DMAE products. But if you are looking to buy DMAE online then you really need to be careful as most of the sources that sell these products are not so reliable. So instead of risking your health and money on some random untrustworthy product go for genuine sources such as Buy DMAE Online at this Link. They produce 100% genuine products which are guaranteed to provide the desired results.
- In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation.
- Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies.
- Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states.
- Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine.
- Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro.
- On the role of cross-linking of cellular proteins in aging.
- Therapeutic strategies against tardive dyskinesia. Two decades of experience.
- Electron spin resonance spectroscopic demonstration of the hydroxyl free radical scavenger properties of dimethylaminoethanol in spin trapping experiments confirming the molecular basis for the biological effects of centrophenoxine.
- Effect of six months of treatment with V0191 in patients with suspected prodromal Alzheimer’s disease.
- Systematic review of cholinergic drugs for neuroleptic-induced tardive dyskinesia: a meta-analysis of randomized controlled trials.
- Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams.
- The influence of DMAE and its parent substance hemicholinium on intestinal contractions in the dog.
- 2-Dimethylaminoethyl-4-methyl-5-ethyl-3-pyridazone (DMAE MEP or Ag 148) cardiovascular analeptic, vasodilator and hypertensive agent.
- A study of 2-dimethylaminoethanol (DMAE) in various forms of psychoneurosis.