Diindolylmethane: Benefits, Uses and How to Prevent Cancer

Diindolylmethane:Benefits, Uses and How to Prevent Cancer

Overview Of DIM: Is Prevent Cancer

You can use Diindolylmethane (DIM) supplements for several health benefits that you can also avail from vegetables like Broccoli. This supplement has amazing cancer-fighting properties. The same can be said about vegetables that contain Diindolylmethane. In addition to Diindolylmethane, they also have a chemical called indole-3-carbinol. The fact that these vegetables are 100% natural means they have better efficiency.

In situations where you do not consume a lot of vegetables, Diindolylmethane supplements can still protect you against a nuisance like cancer.

DIM Prevent Cancer

DIM Prevent Cancer

Diindolylmethane works in your system when you have been taking it for some time. It is a supplement that creates a preventative measure for a disease that is virtually incurable.

What is Diindolylmethane (DIM)?

Diindolylmethane, also known as DIM, is actually created inside the human body. It is a result of the process of digestion of certain vegetables. These vegetables include broccoli, brussels sprouts, turnips, cabbage, cauliflower, kale, and several others from the Brassicaceae family.

Basically, composition wise, Diindolylmethane is the dimeric form of I3C. Indole-3-carbinol is another name for I3C. You can find I3C as a key component in the above-mentioned vegetables in very high concentrations.

You can use Diindolylmethane as the first line of treatment for BPH. It also is an effective option for treating PMS symptoms. Other amazing properties of Diindolylmethane include the fact that you can use it as an anti-inflammatory, antiproliferative, antiviral, anti-angiogenesis, antiandrogenic, antibacterial and even for hormone-balancing!

As a supplement, Diindolylmethane comes with many benefits for the human body.

DIM
DIM
Hormone Supplement
Estrogen Estrogen
Testo- sterone Testo- sterone
Body- building Body- building

How It Works:

  • It has anti-oxidant and anti-inflammatory benefits.
  • Helps in reducing the effects of excess estrogen.
  • Aids in promoting hormonal balance in men and women.
Dosage:
Between 100 – 600 mg per day
Safety:
Rated Possibly Safe


Diindolylmethane (DIM) Benefits For Men

DIM influences men’s health by affecting a simple androgen in their body called Testosterone. This androgen helps in to maintain their hormonal balance. The dominating qualities in men are significantly influenced by the consumption of DIM, which positively affects the levels of testosterone in their bodies.

Testosterone boosts the development of body hair, a deeper voice as well as the male reproductive organs.
In addition, testosterone is also responsible for the synthesis of protein in the body. This protein in turn helps in the development of muscles, stronger bones and improves the response of the male body to exercise.

DIM Helps to Boost Testosterone Level

DIM Helps to Boost Testosterone Level

Essential functions such as increasing the metabolic rate and consumption of fat are also aided by testosterone. It actually leads to a leaner physique in men.

Not only that, testosterone also improves libido and mood. In fact, feelings such as depression and stress tend to stay away from men when their levels of testosterone increase. Men feel more inclined and interested towards sex due to a boost in testosterone.

Higher testosterone levels also reduce the chances of developing cancer in males.

In short, males can positively improve their personality by using a regular dose of DIM.

Keep in mind, estrogen negatively affects the influence of testosterone. It is found in most vegetables such as cabbage, broccoli, etc. DIM counteracts the effects of estrogen in the body and allows testosterone to do its job properly.

DIINDOLYLMETHANE BENEFITS FOR WOMEN

DIM has different yet very healthy effects. Women go through 3 main cycles in life listed as follows:

  • Puberty
  • Menstrual Cycles
  • Menopause

In all 3 of these cycles, women experience a sharp hormonal imbalance. DIM simply has the capacity to normalize the level of hormones in women.

DIM Helps Estrogen Level

DIM Helps Estrogen Level

DIM contains indole 3-carbinol (I3C). It reduces the risk of several types of cancers that women are generally at the risk of contracting. These types include breast cancer, cervical cancer and other estrogen-driven cancers. Estrogen which is found in vegetables like cabbage, broccoli, cauliflower, brussel sprouts, collards, kale, radishes, mustard greens, watercress, and turnips increases chances of cancer in most women.

DIM simply maintains a very good balance between good-estrogen and bad estrogen in women’s body!

Women experience the following benefits by using DIM on a regular basis.

  •  It relieves PMS (Pre-menstrual Syndrome)
  • It reduces painful periods (Controls cramps and related effects)
  • Creates alleviation in Peri-menopausal symptoms
  • Relieves menopausal and postmenopausal symptoms

In addition, consumption of DIM generates progesterone in women’s body. It does not work against estrogen but counters it with progesterone levels in the body. In fact, it simply converts the estrogen in metabolites that can be used for improving several essential functions of the body.

Some of the most pronounced benefits for women include the following:

  •  Works as a hormone balancer.
  • Reduces or eliminates hot flashes.
  • Reduces vaginal dryness.
  • Reduces depression rising due to low estrogen.
  • Supports a healthy libido.
  • Improves adrenal glands.
  • Improves the functions of thyroid and pancreas in the body.
  • Helps in neurotransmitter hormone production which includes melatonin.

While in men, DIM helps in reducing levels of estrogen, in women, DIM does an opposite function. Since, women’s body cannot avoid the use of estrogen, DIM simple changes estrogen into something better!
Make DIM supplement a regular part of your diet for significant improvement in your health.

Why People Use Diindolylmethane (DIM)?

People use Diindolylmethane for several reasons. The most prominent effect of it is preventing the growth of cancer cells.

It contains anti-inflammatory properties that assist in removing certain types of inflammations. It relieves symptoms of arthritis. So far, experiments conducted on animals have shown a significant reduction in arthritis-related inflammation. Along with that, it is also an efficient drug for soothing osteoclastogenesis inflammation, both shown by histological and clinical reports. In this case, Diindolylmethane doesn’t have any preventative effects. It simply works to help patients after the development of arthritis. Arthritis effects are easily controlled through the intervention of Diindolylmethane.

Another fruitful effect that Diindolylmethane has in the case of arthritis is the reduction of receptor activator for nuclear factor kappa-B ligand (RANKL). Suppression of RANKL slows down osteoclastogenesis to a significant extent.

7 Impressive Benefits of Diindolylmethane (DIM)

The core benefits of Diindolylmethane are quite vast. Let’s take a closer look at some of the prominent benefits from Diindolylmethane.

1. Works as an Antioxidant

Although it is not the primary function of Diindolylmethane to work as an antioxidant, it still works as one to control free radicals. The anti-oxidant properties of the Diindolylmethane help in breaking down estrogen into metabolites.

2. Manages Your Weight

Diindolylmethane also controls the production of estrogen metabolites. This helps beat obesity. You can easily lose weight through Diindolylmethane.

3. Provides Support in Menstruation

As stated before, Diindolylmethane plays a vital role in Premenstrual Syndrome. It helps in reducing the discomfort women feel in their breasts and moodiness develop during the menstrual cycle.

4. Supports with Prostrate Health

When you continuously take Diindolylmethane for about 28 days, it supports your prostate health too. It does so by reducing the level of prostate-specific antigen (PSA) in the body.

5. Prevents Breast Cancer

Clinical studies have shown that Diindolylmethane controls the estrogen metabolism in the body. A research was conducted on a few women, who were in their post-menopausal stage suffering from the early stages of breast cancer. Diindolylmethane reduced their symptoms however, it did not treat cancer at this stage. Nutrition and Cancer published this study in 2004.

6.  Prevents Cervical Cancer

The British Journal of Cancer in 2012, published another study. It showed that Diindolylmethane consumption on a regular basis reduces the chances of development of cervical cancer.

7. Prevention of Other Forms of Cancer

You can prevent many other forms of cancer effectively with a daily dose of Diindolylmethane. The other forms of cancer include prostate cancer, colon cancer, and ovarian cancer.

Effects of Diindolylmethane

Many studies have used animals as subjects to determine the effects of Diindolylmethane on the reduction of cancer cells in the human body. Studies that utilize the cell xenografts from the cell line of human breast cancer have shown positive results in this respect.

According to these studies, Diindolylmethane slows down the angiogenesis in cases of breast cancer. Angiogenesis is the process by which the body forms new blood vessels which supply nutrition to the cancer cells. If this process is not contained, it can spread the cancer cells in the body and make it very difficult to stamp out the cancer cells anytime soon.

Diindolylmethane counteracts this process and nips cancer in the bud. It does so by stamping out the growth of vascular endothelial growth factor (VEGF) in the body. Several studies have successfully followed this strategy.

Another way that Diindolylmethane stops the growth of cancer cells in the human body is by slowing down the transitional actions of HIF-1alpha. It is an essential part of the angiogenesis.

How to Take Diindolylmethane?

DIM Supplements

DIM Supplements

You can take Diindolylmethane in its natural form. You can get the Diindolylmethane from I3C in a dose of 2 to 24 milligrams per day. It is quite safe for all healthy people including lactating women, pregnant women, children, and infants. Although this limit casts a safety net around the prescribed dosage of Diindolylmethane, it does not tell us about the recommended dosage of synthesized supplements of Diindolylmethane.

The recommended daily dosage of 300 Milligrams of Diindolylmethane is quite safe if you plan to use the supplement for less than 12 weeks.

A dose of 600 Milligrams per day is not so safe so you should avoid it in most cases. This is a high dose that can cause several side effects for you. In addition, when you are taking the supplements of Diindolylmethane, you should not take any diuretics.

There is a contraindication on the use of diuretics along with Diindolylmethane.

Clinical Evidence for Diindolylmethane

As widely known, there is not much clinical evidence about the benefits of Diindolylmethane as shown by studies. Only very few and specific clinical trials have resulted in success. Western doctors use Diindolylmethane for the treatment of recurrent respiratory papillomatosis (RRP). In RRP, tumors develop in the upper respiratory tract. If Diindolylmethane can counter RRP effectively, it can prevent the formation of tumor in the human body.

In certain cases, Diindolylmethane is also used as a helpful immunostimulating agent to treat many cervical infections. Specifically, women who are suffering from cervical dysplasia are positively affected by 2 mg of a daily dose of Diindolylmethane. This supplement helps in improving the status of HPV as expressed through histological reports. Even colposcopy impressions have shown improvement when you compare them with placebo group subjects.

Clinical proof, howsoever little, shows the remarkable contribution of Diindolylmethane as a therapeutic drug.

Side Effects of  Diindolylmethane

The recommended daily consumption of natural Diindolylmethane is between 2 to 24 Milligrams. This is quite safe for all healthy people including pregnant women, lactating mothers and even children and infants.

However, the supplemental form of Diindolylmethane may have some unforeseen effects. The recommended daily dose of 300 mg may sometimes be accompanied by headaches and an upset stomach.

When you take a higher dose of 600 mg on a daily basis, you can suffer from asymptomatic hyponatremia. It is a condition in which the sodium levels reduce excessively. However, asymptomatic hyponatremia is a very rare side effect.

There are no other recorded side effects associated with the use of Diindolylmethane.

Review of DIM Hormone Supplement

If you are looking for a supplement that helps you in maintaining the hormonal balance in your body, assists in your bodybuilding exercises and protects you from various forms of cancer then Diindolylmethane supplement is the best choice for you. It works as an antioxidant and reduces the estrogen metabolites in the body. It also controls several types of inflammation in the body!

Along with being an effective prevention for uterine, breast and colorectal cancer, Diindolylmethane is also used to prevent an enlarged prostate. An enlarged prostate is also known as benign prostatic hypertrophy (BPH). In some cases, Diindolylmethane also treats Premenstrual Syndrome (PMS).

Although you can use Diindolylmethane supplements for an extended period of time to prevent the growth of cancer in the human body, effective treatment of cancer through this drug seems a bit far from our reach. The US National Cancer Institute is doing research to see if Diindolylmethane can be a good enough cure as it is good enough of a preventive measure.

In the meantime, you can use it as a health booster!

References

  1. The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway.
  2. Indole-3-carbinol as a chemopreventive and anti-cancer agent.
  3. Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.
  4. Changes in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea Var. capitata) cooked for different durations.
  5. Glucosinolates and myrosinase activity in red cabbage (Brassica oleracea L. var. Capitata f. rubra DC.) after various microwave treatments.
  6. Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers.
  7. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables.
  8. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli.
  9. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.
  10. Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables.
  11. Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro.
  12. Oligomerization of indole-3-carbinol in aqueous acid.
  13. Structure-activity relationships of dietary indoles: a proposed mechanism of action as modifiers of xenobiotic metabolism.
  14. Quantitative combination effects between sulforaphane and 3,3′-diindolylmethane on proliferation of human colon cancer cells in vitro.
  15. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.

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