Coenzyme Q10 or CoQ10 is a natural antioxidant found in almost all the cells of the body. This compound is responsible for generating energy in the cells and breaking down free radicals, the damage-causing molecules produced in the body.
Although the human body produces CoQ10 naturally, its production tends to decrease with increasing age. However, you can still keep your CoQ10 levels replenished by consuming certain foods that are high in CoQ10 and supplements.
Researchers have conducted several clinical studies to investigate the effects of CoQ10 in the human body and have found it to have a wide variety of health benefits. Studies have found that low levels of coenzyme Q10 in the body are linked to health conditions, such as heart disease, diabetes, cancer, and brain disorders.
Coenzyme Q10 is a compound produced by the body and stored in the mitochondria of the cells. The mitochondria do not only produce energy but also shield the cells against oxidative damage and harmful viruses and bacteria that are bound to cause diseases.
While increasing age is the major factor when it comes to a CoQ10 deficiency in the body, other causes may include:
- Mitochondrial diseases
- Oxidative stress due to aging
- Nutritional deficiencies, such as a deficiency of vitamin B6
- Side effects produced by statin treatments
- Genetic defects hindering the CoQ10 synthesis or utilization
- A disease resulting in increased demands by tissues
Although CoQ10 is naturally present in almost all cells of your body, the organs with the most energy demands typically have the highest concentrations. These organs include the heart, lungs, liver, and kidneys.
CoQ10 transfers energy within the cells by making Adenosine Triphosphate (ATP). The fact that ATP carries out all the functions of the body and oxidative damage destroys the cells, it is easy to see why some chronic health conditions are linked to low levels of CoQ10.
Coenzyme Q10 is a natural antioxidant that does not allow the free radicals to build up in the body, as their accumulation is not good for health. CoQ10 along with other antioxidants that naturally exist in the body turn the free radicals into harmless substances, serving as the body’s built-in defense.
Furthermore, CoQ10 plays a crucial role in converting the food you eat into energy to fuel up your body and mind. The beneficial effects of CoQ10 are, however, not limited to energy production. Experts believe and clinical evidence suggests that this natural compound may help greatly with many health issues, including diabetes, heart disease, immune function, cognition, and migraines because of its amazing antioxidant properties, its role in energy production, and its ability to prevent blood clotting.
- It promotes energy production from cellular levels.
- Combats aging as it is an anti-oxidant.
- It supports general wellbeing and also improves cognitive abilities.
Coenzyme Q10 is a fat-soluble, vitamin-like compound that offers a number of wonderful health benefits.
It serves as an excellent anti-oxidant agent and is responsible for the production of cellular energy. The beneficial properties of this compound make it helpful in preserving the cells, and preventing and treating many chronic diseases.
Moreover, this natural compound promotes heart health and improves blood sugar regulation. It also helps prevent and treat cancer, and reduce the occurrence of migraines.
Since the production of CoQ10 decreases with age, adults may benefit by consuming more of it through certain foods and supplements. The human body seems to tolerate CoQ10 in the form of a supplement really well. Some foods rich in this coenzyme include vegetables, animal organs, and legumes. Whether you decide to eat more foods that contain high CoQ10 content or take supplements, this natural compound will surely benefit your health and overall well-being.
Coenzyme Q10 is a vital compound required for the optimal functioning of many organs and chemical reactions in the body.
The mechanism of action of CoQ10 mainly involves supplying energy to the cells in the body. It also shows amazing anti-oxidant activities in the body. People with certain diseases, such as Parkinson’s disease, heart failure, blood infection, HIV infection, gum disease, high blood pressure, and certain diseases of the muscles are likely to have lower levels of CoQ10 in their bodies.
Since coenzyme Q10 is a part of the energy-producing cells in the body, it is found in concentrated forms in tissues that demand the most amount of energy. This CoQ10 content in your body is crucial for its function.
Your body tends to show certain signs of CoQ10 deficiency.
Both animal and human studies have found a significant relationship between decreased levels of CoQ10 and a wide range of diseases.
This compound typically exists in high concentration in the muscle cells of the heart and so its deficiency may lead to cardiovascular complications, including angina, heart failure, arrhythmia, and high blood pressure levels.
In addition to this, CoQ10 deficiency may also result in problems related to gum health, blood sugar regulation, and stomach ulcers.
People who take statins to reduce their blood cholesterol levels are especially at a high risk for CoQ10 deficiency. The reason is that statins, in addition to lowering cholesterol levels in the blood, block the synthesis of coenzyme Q10 in the body. Thereby, patients on statins who have considerably low levels of CoQ10 have high chances of experiencing the common side effects of statin therapy, including excessive fatigue and aching joints and muscles.
In general, all the people who have crossed the age of 40 are at risk for developing a CoQ10 deficiency. While in the adult age, the human body fails to produce as much CoQ10 as it did when you were younger, your body does not consume any less amount than it previously did. Hence, the CoQ10 production cannot keep up with the level of consumption.
This deficiency of CoQ10 is most marked in the elderly, individuals taking certain prescription medicines, and those with any genetic abnormalities that interfere with production. Furthermore, vegetarians and athletes are likely to have low levels of CoQ10 in their bodies. In individuals who work out, the high metabolic demands of overworked muscles produce an army of free radicals – and their bodies cannot produce enough CoQ10 to keep up.
The common signs and symptoms of CoQ10 deficiency include:
- Muscle weakness
- Kidney failure
- Learning disabilities
- Hyper reflexes
- Weakened eye muscles
- Atrophy of muscle tissue
- Cerebral atrophy
- Lactic academia
- Sensorineural deafness
General dosage level,
The dosage recommendation of CoQ10 typically varies depending on certain factors, such as your age, weight, and your reason for taking the supplement. However, you should take between 90 to 200 mg per day as per the general guidelines.
How Much Coq10 Does An Adult Need
Adults taking statin medications and those with a family history of heart complications or those at risk of developing a cardiovascular disease should consider taking at least 90 to 120 mg of CoQ10. Healthy individuals, both men and women, may also follow this dosage level to be on the safe side and maintain a healthy cardiovascular system.
As we mentioned earlier, CoQ10 is fat-soluble and hence, you would want to take it with a meal that contains fat. However, if you want to use coenzyme Q10 as a standalone supplement, consider using it in the soft gel form, as it has anti-oxidant properties that are more prominent.
Here is a general guideline for adults who wish to take CoQ10 supplement orally.
- For CoQ10 deficiency: 150 to 2400 mg daily
- For mitochondrial disorders: 150 to 160 mg per day
- For age-related vision loss: A specific product containing 100 mg of acetyl L-carnitine, 530 mg of omega-3 fatty acids, and 10 mg of coenzyme Q10 every day for a year
- For heart failure: 100 mg daily divided into two or three smaller doses continued for up to 4 months
- For HIV/ AIDS: 100 to 200 mg every day for over 4 years
- For multiple sclerosis: 500 mg twice a day daily for 3 months
- For muscular dystrophy: 100 mg per day for 3 months
- For Peyronie’s disease: 300 mg daily for 6 months
- For diabetes-related nerve damage: 400 mg daily for 12 weeks
- For preventing migraines: 150 mg once a day or 100 mg thrice per day
How Much Coq10 Does A Child Need
We would recommend you talk to your child’s pediatrician before starting them on CoQ10 supplementation.
Here are some general dosage recommendations of oral supplementation of CoQ10 that you should follow for your child.
- For CoQ10 deficiency: 60 to 250 mg per day divided into three smaller doses
- For preventing migraines: 1 to 3 mg/kg every day for 3 months seem to work in children aged 3 to 18 years
- For muscular dystrophy: 100 mg per day for 3 months seems to work safely for children aged 8 to 15 years
Coenzyme Q10 works as an excellent, natural anti-oxidant.
The primary function of anti-oxidants is to look for the free radicals in the body that give way to oxidative stress. Free radicals are actually a by-product formed as a result of metabolism and are equally natural. They, however, produce at a much higher rate when you expose your body to sunlight, smoke, exhaust, and poor diet and alcohol consumption.
The free radicals in the body seek a stable molecule, as they themselves are unstable. What happens is that they leave the stable molecule unstable and cause oxidative stress. This process may disrupt the healthy cells, cause the death of the cells, and damage the tissues. The same consequences are associated with the aging process – and that is why anti-oxidants are so crucial for you as you grow older.
Coenzyme Q10 is a special, fat-soluble anti-oxidant produced naturally by the human body that exhibits a unique ability to restore back to its original, healthy state after successfully fighting off the free radicals in the body. This makes CoQ10 an invaluable anti-oxidant to combat the effects of aging.
Coenzyme Q10 supplement is potentially safe for use for most adults when they consume it orally or use it as a topical lotion applied directly on the gums. Most users tolerate this supplement really well without experiencing any side effects.
However, CoQ10 supplement may, in some cases, causes certain mild side effects. Here are some common side effects of CoQ10:
- Loss of appetite
- An upset stomach
These side effects are not only rare but also are mild in nature and tend to go away on their own with time. If you experience any of these side effects after supplementing with CoQ10, you do not necessarily have to worry. However, if these symptoms do not get better with time and start getting worse instead, you should consider stopping the supplementation and consulting your doctor or a medical health professional to make sure its use is safe for you.
The key to preventing the side effects of a CoQ10 supplement is to take the right dosage. In case you overdose and experience any serious symptom, you would want to seek immediate medical attention. As long as you take the recommended dosage of the supplement, there should not be a problem. You may also consider dividing your total daily dose into two or three smaller doses to reduce your risk of experiencing a side effect.
Furthermore, CoQ10 supplement is possibly safe for children to use when taken orally. However, medical supervision is a prerequisite for safe CoQ10 supplementation in children.
While CoQ10 supplementation is possibly safe for users, you should take special precautions if you fall into any of the following groups:
- During pregnancy, CoQ10 supplementation is possibly safe. However, if you are a breastfeeding woman, you should avoid its use to stay on the safe side.
- If you have high or low blood pressure levels, you would want to use CoQ10 with caution, as it may lower blood pressure and enhance the effect of medicines taken for the same purpose.
If you have a surgery scheduled in the upcoming days, consider stopping the use of this supplement at least 2 weeks before the due date, as it may interfere with blood pressure control during and after the surgery.
- Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition
- Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus
- Clinical applications of coenzyme Q10.
- Coenzyme Q10 Supplementation in Aging and Disease.
- Overview of the use of CoQ10 in cardiovascular disease.
- Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review.
- Coenzyme Q-10 in Human Health: Supporting Evidence?
- Can coenzyme Q10 supplementation effectively reduce human tumour necrosis factor-α and interleukin-6 levels in chronic diseases? Protocol for a systematic review and meta-analysis of randomised controlled trials
- Coenzyme Q10: The essential nutrient
- Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals
- Coenzyme Q10 Supplementation in Aging and Disease
- Coenzyme Q10
- Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases