Coluracetam Against Depression: How it Works, Review and Effects

Coluracetam Nootropics: Health Benefits, Dosage and Review

What Is Coluracetam?

Coluracetam belongs to the famous Racetam family of the nootropic drugs. It is used to improve memory and to learn among the users. So, if you are a student, writer or belong to any competitive field, Coluracetam might be the drug for you to excel in your job.

It can help enhance your focus and concentration!

Coluracetam is fairly new in the medical field, and there is a lot to be researched about it. Most of the trials pertinent to this cognitive enhancer are still under process; therefore, information about its benefits and side effects are limitedly known. The evidence so far suggests that Coluracetam is highly effective in terms of depression and mood-boosting. It can help you lift your mood and increase your ability to form new memories.

Coluracetam indicates a promising future in the medical world. Its effectiveness – and risks – is dependent on the subsequent scientific research. So far it has demonstrated positive results with marginal risks.

Coluracetam for Focus and Concentration

Coluracetam for Focus and Concentration

Coluracetam Overview

Coluracetam is essentially from the racetam drugs family and was first developed in Japan by the Mitsubishi Tanabe Pharma Corporation. It was designed as a treatment option for Alzheimer’s disease but didn’t prove to be very effective for it in the clinical trials.

So instead, it was approved as a medication for treating the major depressive disorder.

Alongside its memory boosting properties, Coluracetam has been found effectual for helping with conditions like depression and anxiety. A popular dietary supplement, Coluracetam is readily available in markets and online. Research about this precise nootropic is still in process and there are several aspects that remain to be uncovered.

Being a part of the racetam family, Coluracetam shares quite a few characteristics with other supplements like Piracetam, Oxiracetam, and Phenylcetam, etc. It functions in the same manner as other racetams by increasing the choline uptake despite neuron being impaired. Coluracetam has high potential in the medical field, especially in optics. It can help treat optic nerve and retinal injuries, making the vision brighter and clearer.

Coluracetam, so far, has been reported to be a safe drug with nominal side effects. It has demonstrated positive reviews among the users in terms of treating depressive conditions. The following sections explore the positive as well as negative sides of the drug, along with describing the recommended dosage limit and action mechanism of Coluracetam.

Coluracetam
Coluracetam
Racetam Nootropic
Vision Vision
Mood Mood
Brain Function Brain Function

How It Works:

  • It helps in increasing the intake of choline into the neurons.
  • Promotes the functions of acetylcholine.
  • Helps in repairing the brain cells.
Dosage:
150-200 mg per day.
Safety:
Generally Well Tolerated

Coluracetam Dosage Limit

Coluracetam Capsules

Coluracetam Supplement

Coluracetam is still under research. That means its risks and side-effects have not been completely explored yet. According to the extrapolating data, there are a few recommendations made for the dosage limit. The user is suggested to start the drug with a 20mg dose and can increase it up to 80mg per day. It is highly recommended to start off with a low dose and divide the 20mg dose into two 10mg doses, take one in the morning and one in the early afternoon.

Since the drug is still under clinical trials, the effects of higher doses are not known yet as the experiments are under process.  Coluracetam can be consumed in powdered form. Having the fat-soluble property, it is recommended that you should take Coluracetam with a meal comprising of healthy fats, or consume it with liquids like extra virgin, coconut or olive oil. This will ensure quick absorption in your body, and you will be able to experience the effects rather quickly.

Coluracetam is a fast-acting compound. It can get regulated in the blood within 30 minutes, and its effects remain for about three hours. So, whatever extensive mental work you need to get done, it should be executed within this period when the effect of Coluracetam is high.

Coluracetam Mechanism of Action

The lack of research has kept the medical professionals from outlining the exact mechanism of action for Coluracetam. However, this precise cognitive booster drug has been reported to function in a similar manner as that of other racetam compounds. It essentially works through the process of “high-affinity choline uptake.” It increases the choline uptake like other racetam compounds.

What makes Coluracetam different from other fellow family drugs is that it also increases the choline uptake in the damaged neurons. It interacts with the HACU process that is responsible for the absorption of choline in the neurons. The increase in choline uptake is executed during the process of acetylcholine synthesis. Coluracetam, amidst this process, improves the choline preservation and a large amount of it is converted into acetylcholine. This results in increasing your memory, improving your attention and enhancing alertness.

The action of Coluracetam is primarily responsible for countering the inadequate production of acetylcholine. Coluracetam enhances the production of choline by the neurons and increases the presynaptic release of acetylcholine. It tends to activate the HACU process when the demand for acetylcholine becomes high. It is one of the mood enhancing supplements that work really well for depressive disorders and improves the memory formation in the brain by improving the overall level and efficiency of choline.

Ingredients of Coluracetum – Does it really Work? Is it a Scam?

Coluracetum is produced in similar just like any other racetam drug. As most of its ingredients are kept secret by the manufacturers so we know very little about the contents of the drug. However, we do know the chemical formula which is more than enough to satisfy the skepticism in you. the chemical formula of Coluracetum is C19H23N3O3.

Now that you what’s inside the drug you are consuming, the next question that comes to mind is does it really work? Well, the answer to that question is yes it does wok but it depends on the purpose you are taking it for. As discussed earlier, Coluracetum was created as a drug to treat Alzheimer’s disease.

However, it failed to treat it after several tests but instead we got a brand new racetum drug as a result. So if you plan to take as a treatment for Alzheimer’s then it will definitely not work. But if you take it for enhance the mood and increase the cognitive senses then it will certainly deliver the result.

Another question that might arise in your mind is if this drug is a scam or not? As mentioned above it definitely isn’t a scam. It works perfectly for the purpose that it is advertised for.

6 Interesting Coluracetam Benefits & Uses

Coluracetam is a memory supplement that works tremendously well in improving your memory and learning. The drug has been tested to find that it has long-term effects and is beneficial for the treatment of conditions like anxiety and depressive disorders.

Some Of The Benefits Reported For Coluracetam Are Discussed In Detail Underneath:

1. It Can Substantially Improve Your Memory

Your memory is initially associated with the level of acetylcholine in your brain. Patients with Alzheimer’s have low acetylcholine levels in their hippocampus. Using Coluracetam may prove to be beneficial for eliminating some of the Alzheimer’s symptoms as it helps boost acetylcholine level in brain and can assist in improving memory and learning.

Best Nootropic Stack for Memory

Best Nootropic Stack for Memory

2. It Can Aid You in Fighting Depression

Coluracetam is a memory supplement that works colossally in improving your mood as well. While the clinical trials concluded positive results for patients with depression, a high dose of 80mg of the nootropic is required to bring about a positive effect on depression.

3. It Can Help You Overcome Your Anxiety

According to the results of limited trials that have been held on humans for Coluracetam, it has been deduced that this specific memory-enhancing drug is effectual for treating anxiety in individuals. You can consume Coluracetam on a daily basis and can have approximately 21% more benefit than that of other antidepressants like Valium.

4. It Can Assist You in Mental Health Disorders

Mental health disorders such as Schizophrenia may occur due to the impaired functioning of an enzyme responsible for making acetylcholine. The ability of Coluracetam to improve the acetylcholine synthesis process can substantially help you in dealing with Schizophrenia and limiting its effects.

5. It Can Improve Your Eye Health

Though Coluracetam faces a dearth of medical research, it has been found to have a positive effect on the optic health of humans. There are several studies in process, working on the possibilities that Coluracetam has in the treatment of optic nerve and retinal injuries. With the limited data that is available, sufficiently proves that you can utilize Coluracetam for improvising your vision.

6. It Can Promote Your Nerve Cell Growth

Coluracetam is effectual in neurogenesis. The activity of the drug in the brain is presumed to promote the nerve cell growth. This benefit usually comes into effect after a few weeks of Coluracetam consumption and the brain is able to receive a regular supply of the drug.

3 Common Side Effects of Coluracetam

Coluracetam for Improvising Vision and Brain Damage

Coluracetam for Improvising Vision and Brain Damage

No drug, per se, is devoid of risks and side effects. Coluracetam is no exception. Lack of pertinent scholarly data makes it difficult to exactly outline what risks and consequences are incurred during the consumption of Coluracetam. Here are some common side effects that are reported by the users:

1. Expect Headaches

Just like other nootropic supplements, Coluracetam may cause you mild headaches. They can be unpleasant, and you might experience them infrequently. Some users incur painful symptoms on every dosage of Coluracetam. This is usually because of the lack of choline in your brain. You can reduce this side effect by increasing choline supply in your diet.

2. Level of Toxicity That You Should Look Out For In Coluracetam

Since Coluracetam has a very limited history of human use, there is no such evidence reported about the toxicity level in the drug. The research data acquired by the users so far does not indicate any significant negative effect. Though, it is recommended to use it in low dose and then increase the dosage gradually.

3. Addiction Potential of Coluracetam

Coluracetam is not an addictive drug. However, the user certainly can develop tolerance towards it. Chronic use of Coluracetam can lead the user towards developing tolerance towards its impact, and this can compel them to increase the dosage to attain similar effects.

Coluracetam User Review:

Coluracetam, despite its limited research and popularity, enjoys highly positive reviews by the users. It has received more positive reviews than negative on online drug shopping portals, denoting the customer satisfaction it has achieved. Here are some positive and negative aspects of the drug that have been reported by the users:

Positive Aspects

Users who are using Coluracetam for a long period (2 years approximately) are found to be content with the effects the drug has on their body. It is reported to enhance concentration and working capacity in the users and has improved their memory substantially.

Long-term users do not report any negative effects of the nootropic drug and declare it to be safe. They did not develop any tolerance and are using the same dosage level.

Adverse Aspects

According to reviews, some of the users reported experiencing daytime drowsiness after the consumption of the drug. Though the feeling isn’t stated to be unpleasant, it was found to be more relaxing and sedating.

Other than this, some users experienced nausea. This is usually associated with the dosage level. As the dose was reduced, the side effects were eliminated.

Where to Buy Coluracetam

Coluracetam is a smart drug that is unregulated by the drug control authorities. It is powerful and effective in its functions. Coluracetam can be beneficial to you in terms of improving your memory, learning and enhancing your mood. It can help you fight depressive disorders and elevate the quality of life.

You can purchase Coluracetam through online vendors and e-commerce websites. However, you have to ensure the authenticity of the drug to avoid quality control issues.

Final Comment of Coluracetam

So far the user reviews and feedbacks have been positive when it comes to the effectiveness of Coluracetum. It works perfectly the deliver the desired result if taken according to the prescription and in the right amount. However, it is still a fairly new drug and as mentioned earlier there have not been extensive research on it to rule out any major or minor side effects.

Despite the lack research oriented results many physicians assure that Coulracetum is safe to use and even if someone mistakenly takes a high dosage then it isn’t a worrying situation as it might only cause mild side effects.

Coluracetum has certainly earned its place in the family of racetum drugs. If you are looking give it a try then remember to start with small dosage and then gradually build up to higher ones. The reason to start with small dosage is to see if your body accepts it or not. Every human body is different in many ways which is why drugs also react differently for everyone.

Coluracetum is also known to treat people with depression rather effectively. So if you know anyone feeling low and suffering from immense sadness then recommend them to use Coluracetum.

References

  1. MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.
  2. PCP: from pharmacology to modelling schizophrenia.
  3. Subsequent exposure to the choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons in rats.
  4. Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.
  5. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats.
  6. Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer’s disease: an autoradiographic study using 3H-hemicholinium-3.
  7. Evidence for high affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer’s disease.
  8. Regulatory changes in presynaptic cholinergic function assessed in rapid autopsy material from patients with Alzheimer disease: implications for etiology and therapy.
  9. Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo.
  10. MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.
  11. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats.
  12. MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.
  13. Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter

 

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