Ten Lesser-Known Surprising Benefits of Citicoline

What Are the Benefits of Citicoline for Your Brain Health?

Do you know that your brain makes up 2% of your body weight?

Also, it consumes nearly 20% of your body’s energy while it is resting. This can give you a vivid idea about how much energy it would require to function optimally throughout the day. If you want to keep your mind sharp, observant and alert throughout the day, you have to give it substantial nutrition that is necessary for its optimal functioning.

You may wonder what nutrition your brain requires. Well, it is citicoline – a naturally occurring compound that serves as a huge support to your brain. Also known as CDP-choline, it is crucial for your cognitive abilities and performance. Citicoline is found in every cell of your body and has a significant role in all areas, but its presence is particularly significant in the brain. It helps in boosting your cognitive functions and mental abilities, making you a sharp and more intellectual person.

Existing naturally in the human body, citicoline is also present in some uncommon dietary sources that you may not consume as often. Available as a cognitive enhancer and brain supplement that can boost your overall mental performance. Citicoline speeds up your ability to perform cognitive tasks, memory formation and recalling tendency. It helps in improving your attention and focus.

Besides cognitive functions, citicoline plays an essential role in accelerated recovery from stroke. There are several benefits of citicoline that are lesser known to the world. This post sheds light on the various positive effects of citicoline on your body and brain. Let’s get on with it and explore how you can benefit from this naturally existing compound.

What Is CDP Choline?

Citicoline is also known as CDP Choline or cytidine 5- diphosphocholine. Serving as a building block of cell membranes, citicoline exists in the human body naturally. It subsists in every cell across the body but remains abundant and plays a crucial role in the brain.

Dietary sources such as beef liver and brain are rich in citicoline. These food items are not commonly found in the western diet. Other sources for citicoline include eggs, beef, and seafood. The structure and functions of citicoline are similar to choline. It helps in the healthy regulation of neurological functions such as mental energy, memory, and focus.

Citicoline uses choline as a precursor to instigate its synthesis and then gets converted into a phospholipid, phosphatidylcholine that is an essential component for cell membranes.  Citicoline, on breaking, forms choline and cytidine. Cytidine is a component that makes up your DNA and RNA.

Having the ability to produce cytidine, citicoline offers additional advantages in the production of the nucleic acids that are necessary to carry genetic information. Citicoline plays an imperative role in diminishing the possibility of cognitive decline and impaired memory.

Cholinergic Supplement
Memory Memory
Focus Focus
Brain Health Brain Health

How It Works:

  • It helps in promoting focus, memory, and mental clarity.
  • Acetylcholine neurotransmitter levels increase due to citicoline.
  • It works efficiently to improve the health of the brain cells and the communication between them.
Between 250 – 2,000 mg per day
Rated Likely Safe

Top Ten Hidden Benefits of Citicoline

Citicoline use among individuals shows constructive effects. Several clinical trials support its ability to boost memory and enhance general cognition. There are a lot of presumptions pertinent to the benefits of citicoline and many of them are widely acknowledged. Here are some of the lesser known benefits of citicoline that may surprise you. Let’s have a look at them one by one:

1. Low Choline Levels Will Cause Liver Damage

Choline is an essential nutrient and liver helps in its metabolism. When the level of choline diminishes from your body, it causes liver cell death, resulting in damaging your liver. To maintain efficient functioning of your liver, it is imperative that choline levels are effectively maintained.

2. Choline May Decrease Inflammation

There is an inversely proportional relation between inflammation and citicoline. A higher level of citicoline reduces the symptoms of inflammation. An adequate amount of choline activates the acetylcholine receptors that are anti-inflammatory in nature.

3. Choline Helps In Improving Intelligence

The compound responsible for boosting your intelligence and IQ level is myelin. To ensure ample presence and functioning of myelin, choline is necessary because it serves as a nutrient for myelin. When you take citicoline rich dietary sources or supplements, the synthesis and nutrition of myelin arise and it ultimately inflicts positive result on your cognitive abilities.

4. Citicoline for Your Brain Energy

As mentioned, your body utilizes 20% of your body energy (oxygen and calorie) when it is resting. This denotes the amount of nutrition it requires to function optimally. Brain demands constant energy supply but cannot store the energy to use as per convenience. Citicoline offers energy to your brain by regulating glucose metabolism and enhancing the blood flow to the brain.

5. Citicoline Enhances Your Learning and Memory

The supplements of citicoline are essentially nootropic brain supplement formulas. Developed from natural or pharmaceutical substance, they improve mental functions and abilities, especially memory, intelligence, and motivation. Citicoline serves a similar function and is safe to use.

6. Citicoline Helps Your Brain Defend

Your brain bears the tendency to allow certain nutrients, water and oxygen to enter that are essential for the survival of brain cells. This denotes the semi-permeable properties of brain cells. Several harmful elements and substances can use this opening to enter the cells and damage your brain. Citicoline plays a critical role in retaining the integrity of your cell membrane and keeps the toxins, pathogens and other metallic wastes at bay that can potentially harm your brain.

7. Citicoline Slows Aging of Brain Cells

Your brain cells are under the consistent invasion of free radicals that can cause tremendous damage. Fighting these radicals consistently results in accelerated aging of your brain cells. To reduce the negative impact of these radicals and protect your brain from aging, citicoline fights back the malignant attacks. It reduces the inflammation caused by these radical attacks that are a major cause of cellular aging.

8. Treating Neurological Disorders with Citicoline

Citicoline supplements review showcase a positive effect of the compound on various medical conditions. As a matter of fact, the initial purpose of citicoline was to help the victims of stroke. The trend of using citicoline as a cognitive enhancer has arisen only recently. But before that, it was a prescription-only medication. Citicoline shows a constructive effect for cognitive problems and neurological conditions, namely: age-associated memory loss, stroke, dementia, Alzheimer’s and Parkinson’s disease.

9. Mental Health Disorders and Citicoline

Addiction-related mental health disorders are rapidly picking up the pace and an alarming portion of the population remains affected by it. Citicoline possesses the tendency to help the addiction victims overcome their problem. Citicoline increases the level of dopamine in the brain and eventually curtails the person’s craving for the illicit substance. This is especially effective for cocaine addicts.

10. Citicoline and Weight Loss

There isn’t much evidence available for this particular benefit of citicoline, but users report a positive response stating that using citicoline decreases appetite which ultimately contributes to weight reduction. This is because citicoline alters your brain’s response with respect to food stimuli and decreases your inclination towards food.

Clinical Use of Citicoline

There are several clinical areas in which citicoline showcases promising results. Even though there is a substantial gap in literature available to demonstrate the exact effects of the compound, the so far acquired results point toward a bright future for citicoline in the medical field.

A number of European countries are using citicoline for medicinal purposes. The trend is not as common in the United States yet, but as the awareness continues to spread, the use of citicoline will increase substantially. Initially designed for stroke treatment, citicoline helps in several clinical procedures. The scientific research shows that citicoline is effective in regaining cognitive function and repair the neural damage incurred during strokes. This nootropic drug helps in strengthening the brain connections and supports the development of new neurons. This makes citicoline highly beneficial in the recovery of stroke patients. According to a study, a stroke patient can recover in three months time if they receive 500-2000 milligrams per day citicoline within 24 hours of an acute ischemic stroke.

The clinical use of citicoline entails situations of cognitive decline as well. From patients of dementia to age-related memory loss, citicoline use shows a constructive improvement in cognitive health. Considering the positive growth of citicoline, it may benefit the patients of Alzheimer’s as well. Several research studies are under trial to explore the capability of citicoline to treat Alzheimer’s patients as the findings indicate that the affected individuals possess less than normal levels of acetylcholine. Clinical potential of citicoline is promising for other health conditions, like ADHD, as well where the patients face difficulty in retaining their focus.

Citicoline still needs substantial research to unveil its medical benefits and uses completely. Moreover, it is not approved by the Food and Drug Administration so far, which restricts the availability of citicoline as a health supplement only.

Best Nootropics Stack for Citicoline

In the areas of cognitive disorder management, citicoline demonstrates positive effects when combined with other nootropics. Combination of citicoline with Piracetam shows constructive results in improving the flow of cerebrospinal fluid of the brain. When combined, they can easily pass through the blood-brain barrier. Stacking citicoline with Piracetam helps in memory enhancement, improving neurological and cognitive disorders and vasospastic disorders. Among the age-related diseases, stacking citicoline with Piracetam can help in Parkinson’s and Alzheimer’s disorders. They also report positive effects for depression and anxiety stroke, closed craniocerebral trauma, dyspraxia clotting, and coagulation.

Stacking citicoline with Bacopa monnieri can serve as an ultimate memory booster. Where citicoline supplies choline to synthesize acetylcholine, Bacopa monnieri enhances the production of acetylcholine in the brain by stalling the enzyme, acetylcholinesterase that breaks down acetylcholine.

Another nootropic with whom you can stack citicoline is Rhodiola Rosea. The latter nootropic helps in limiting the negative effects rendered by the stress hormone, cortisol. Cortisol, essentially, promotes adaption of stress in your mind and body. Excessive presence of cortisol can damage cognitive efficiency.

So, Rhodiola Rosea works well with citicoline and offer tremendous energy to the brain to perform in the best possible manner. When you stack Rhodiola Rosea with citicoline, it results in generating natural energy that facilitates several cognitive health benefits. This includes increased neurotransmission and synaptic plasticity. The stacking of these two nootropics allows you to sustain brain energy for a longer period of time and eliminate the possibility of side effects that occur commonly with other typical stimulants.

User Review for Citicoline

Users report citicoline as a safe nootropic supplement that is more tolerable than the placebo. While there is not enough research to determine the exact effects, negative and positive, the user reviews, however, indicate a promising future for citicoline. There are no safety issues reported with the Citicoline treatment.

According to the reviews shared by the users, citicoline effectively enhances their ability to focus and pay attention. They feel mentally more energetic and strong. Users also report a positive experience of stacking citicoline with other nootropics such as Piracetam and other members of the Racetam family.

Some user state that stacking citicoline with piracetam helped in reducing the potential of negative side effects. Citicoline is convenient to carry and use at any time of the day. Some users complain that it is an expensive supplement. Citicoline powder is available in lower cost. You can mix it with water and consume easily.

The experience of users indicates that citicoline is easy to use a supplement that gets absorbed well and rarely causes any adverse reactions. However, some user report dizziness, headaches, and anorexia when they take a higher dose of citicoline.

We recommend you to start with a smaller dosage of citicoline and gradually increase the daily intake so that your body receives adequate time to get accustomed to it. Also, it is beneficial and safer to get your doctor’s opinion on the dosage level so that you do not experience any problems.


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