Cissus Quadrangularis: Uses, Benefits, and How It Works – NOOTRIMENT

Cissus Quadrangularis: Uses, Benefits, and How It Works

Overview of Cissus Product – “Bone Setter”

Cissus Quadrangularis is a perennial plant with medicinal properties. People have traditionally used it to treat certain feminine conditions related to menopause, libido, and menstruation, and various bone disorders – hence given the name ‘bone setter’.

Cissus helps to recover bone disorder

Cissus helps to recover bone disorder

Today, many athletes and bodybuilders use it as a workout supplement in replacement of anabolic steroids to improve their body composition and help their bones recover from strain or damage.

Despite belonging to ancient times, Cissus Quadrangularis still serves as an effective therapeutic agent. Millions of people across the globe use this succulent vine for a wide range of medicinal purposes.

You may find this plant by other common names, including Devil’s Backbone, Hadjod, Veldt Grape, and Asthisamharaka.

What is Cissus Quadrangularis?

Also known as Vitis Quadrangularis, it is a rambling shrub with a thick, fleshy quadrangular stem, reaching a height of 1.5 m.

Cissus Quadrangularis plant belongs to grapes in the Vitaceae family. Its origination links to Africa and some parts of Asia, including Sri Lanka, Thailand, and India. Today, people export it to Brazil and the southern areas of the United States. The African and Indian medicinal systems have always used this plant to treat different medical conditions.

Cissus Quadrangularis
Herbal Supplement
Bone Health Bone Health
Bodybuilding Bodybuilding
Weight Loss Weight Loss

How It Works:

  • It helps the muscles relax and acts as a sedative.
  • Helps in reducing pain and monitoring joint health.
  • Helps in weight loss and recovery from work-out.
Between 150 – 600 mg per day
Generally Well Tolerated

Main Purpose of using Cissus Quadrangularis

Given the presence of so many compounds in the plant, Cissus Quadrangularis is effective in treating numerous conditions.

Cissus Quadrangularis for weight loss

Did you know that more than one-third of Americans are obese and/or overweight?

The x-factors for obesity include lack of physical activity, poor food choices, and large portion sizes. Hence, maintaining the health of the digestive tract is important for losing and maintaining weight.

Best way to lose weight using cissus

Best way to lose weight using cissus

Cissus Quadrangularis supplement may help people achieve their weight loss goals by controlling their appetite  and blocking the absorption of certain fats and carbohydrates. This supplement may help in eating a healthy and well-balanced diet, making proper food choices, choosing sensible portion sizes, and getting adequate levels of physical activity.

One study found that taking Cissus Quadrangularis supplement twice a day before meals resulted in significant weight loss for obese people. In another study, researchers concluded that Cissus Quadrangularis supplementation leads to reduced body weight, fasting blood glucose measurements, cholesterol levels, C-reactive protein, and triglycerides.

Cissus Quadrangularis for liver function

Cissus Quadrangularis also improves the detoxification process by promoting liver health and functioning. This further helps in losing weight because of the accumulation of fat and poor health of the digestive tract often creates challenges for the liver related to oxygen synthesis and inflammation.

Better functioning of liver results in a better elimination of toxins and waste products. This enables the bodily systems to function efficiently while expending less energy. This further results in significant improvements in the general health over time. The prominent improvements include an enhanced ability to break down, digest, and utilize foods, and then efficiently expelling out the waste products.

Cissus Quadrangularis for bodybuilding

Recent research suggests that Cissus Quadrangularis supplementation may prove effective in building muscle mass.

Typically, when people work out in the gym to increase their muscle mass, they lift weights. Weightlifting leads to the release of anabolic hormones, including testosterone and growth hormone, from the endocrine system. But due to the stress on their body, cortisol also releases, which inhibits protein synthesis and promotes degradation of amino acid. Hence, the release of cortisol is bad for bodybuilding.

Studies indicate that Cissus Quadrangularis binds and interacts with the glucocorticoid receptor (GR) and serves as a GR antagonist. By doing so, it prevents cortisol from binding to the receptor and hence, reduces its levels to promote muscle building.

The most common uses of Cissus Quadrangularis include:

    • Bone fractures
    • Bone defects resulting from gum disease
    • Joint pain
    • Hemorrhoids
    • Obesity and weight loss
    • Allergies
    • Bodybuilding
    • Asthma
    • Cancer
    • Diabetes
    • High cholesterol levels
    • Gout
    • Anorexia nervosa
    • Osteoporosis
    • Body pain
    • Malaria
    • Painful menstruation
    • Seizures
    • Scurvy
    • Peptic ulcer disease
    • Arthritis
    • Metabolic syndrome
    • Wound healing
    • Upset stomach

How Does Cissus Quadrangularis Works

There are multiple mechanisms of action of Cissus Quadrangularis extract.

Modern research shows that Cissus Quadrangularis may have antioxidant, analgesic, and anti-inflammatory properties. This further suggests that it might be beneficial in treating various metabolic disorders, obesity, and osteoporosis.

In addition to this, according to the phytochemical analysis of this plant, it contains high levels of ascorbic acid or vitamin C, carotene, calcium, and anabolic steroidal compounds.

Researchers also believe that the stem of this plant has two asymmetric tetracyclic triterpenoids as well as two steroidal substances, beta-sitosterol, gamma amyrin, gamma amyrone, and flavonoids. The presence of these compounds indicates that Cissus Quadrangularis may also exhibit pharmacological effects.

Top 4 Benefits of Cissus Quadrangularis

Following are some amazing benefits of Cissus Quadrangularis plant.

1. Strengthens bones and skeletal system

Cissus Quadrangularis extract has bone formation and anabolic properties.

Patients with jaw fracture injuries use it to relieve pain and reduce swelling. It also helps patients with facial fractures in the healing process by increasing the levels of calcium and phosphorus in their bodies.  Studies have also found this plant to be beneficial in reducing joint pain in healthy men.

2. Regulates hormones and aids in weight control

Upon Cissus Quadrangularis supplementation, patients experienced a reduction in their weight as well as in their cholesterol, blood glucose, and triglycerides levels.

When overweight patients took 300 mg of this herbal supplement, they noticed a significant improvement in their serotonin levels and a reduction in their weight.

Furthermore, rat studies have found that this plant helps improve estrogen levels upon menopause onset. It also shows anti-diabetic properties and by promoting insulin sensitivity and reducing liver damage, while bringing the lipid and antioxidants level back to normal.

3. Promotes blood health

Research indicates that in humans, the methanol extract of Cissus Quadrangularis helps lower down the levels of alkaline phosphatase, alanine transaminase, aspartate transaminase, and bilirubin. By doing this, it shows blood-protective properties because high levels of these may prove toxic for the blood.

4. Benefits of the gastrointestinal tract

Cissus Quadrangularis promotes cellular reproduction and thus, helps in the healing process of an ulcer.

A rat study found that this plant reduced gastric secretions and increased gastric mucin content and the level of glycoprotein in rats with induced ulcers.

According to another rat study, rats with aspirin-induced ulcers when given Cissus Quadrangularis extract experienced a noticeable reduction in the ulcer size. Also, it helped restore their protective mucus layer.

Recommended Dosage Level of Cissus Quadrangularis Extract

Cissus Quadrangularis Supplements

Cissus Quadrangularis Supplements

Since Cissus Quadrangularis is a natural supplement, it is noteworthy that its safety status may vary from person to person due to individual differences.  Therefore, we recommend you to talk to your doctor before taking this supplement just to make sure that it will not produce any significant side effects for you.

Once given the green signal, you may start taking it. However, remember that the right dosage is the key to enjoying its benefits.

If you are looking forward to using it as a dietary supplement, note that the recommended dosage of Cissus Quadrangularis will depend on your age, gender, your current health status, the medical condition that you are using it for, and other health factors.

You will typically find this supplement in the form of 500 mg capsules, containing a 20:1 extract power. We suggest you go through the dosages that the manufacturer has mentioned and the warnings on the packaging. And of course, seek the advice of a medical professional.

If you want to take this supplement for fitness purposes, you should consider taking a daily dosage of 600 mg to 1000 mg, divided into two smaller doses. However, in an extreme case like a fracture, you may take a higher dosage of 2000 mg.

The ideal way is to start by taking lower dosages to see how your body reacts to it. If need be, you can later increase the dosage over time.

Clinical Evidence for Cissus Quadrangularis

While several clinical studies aiming to investigate the possible health benefits of Cissus quadrangular extract are in their beginning phases, there are many others showing a positive result.

 The Clinical evidence for Cissus Quadrangularis is pretty rich. Well-known journals have published the following clinical observations regarding the supplementation of Cissus Quadrangularis extract.

  • Increases the serotonin levels in plasma by as much as 35%.
  • It increases the levels of creatine in the body.
  • Reduces the rate of lipid peroxidation.
  • It helps in achieving and maintaining a healthy weight.
  • Its supplementation leads to a significant reduction in LDL and blood cholesterol levels.
  • It considerably reduces the number of triglycerides.
  • It helps athletes suffering from joint stress relieve their pain to a significant extent.

 In addition to yielding some wonderful benefits for humans, Cissus Quadrangularis extract also seems to work wonders when it comes to rodent testing. Consider the following clinical observations.

  • It shows sedative properties – it reduced sleep latency by up to 40% and increased the length of sleep.
  • It has anti-seizure properties – it dropped the convulsion rates of induced seizures by as much as 70%.
  • Exhibits analgesic effects – it reduced the general pain responses by about 60%.
  • Its supplementation led to an improvement in the capacity to heal free radical damages.
  • It has anti-diabetic properties – it improved insulin sensitivity and enhanced the bioavailability of insulin.
  • It has antioxidant effects – it considerably reduced the H2O2 mediated oxidative damage.

What are the Major 10 Potential Side Effects of Cissus Quadrangularis?

Considering the fact that Cissus Quadrangularis is a natural supplement and its usage dates back to ancient times, it makes sense why most users are able to tolerate it well and find it perfectly safe.

We would leave any comment on the long-term safety of this supplement on the ongoing and future studies. It is crucial that you follow the recommended dosage to be on the safe side.

An inappropriate dosage or an overdose of this supplement may lead to certain side effects – which thankfully are minor and only temporary.

The potential side effects of Cissus Quadrangularis extract include:

  • A headache
  • Irritability
  • Gas
  • Bloating
  • Diarrhea
  • Dry mouth
  • Sleep disturbances

The best way to avoid these side effects is by taking the recommended dosage of the supplement while also following the advice of your doctor.

Another important thing to note here is that certain conditions may not be ideal for Cissus Quadrangularis supplementation. If you fall into any of the below-mentioned categories, this supplement might not be for you.

  • Pregnant or breastfeeding women, or those trying to get pregnant
  • Individuals with type 2 diabetes – because this supplement may induce hypoglycemia
  • Individuals with surgeries scheduled in near future – as this supplement may reduce blood pressure too much, posing a safety risk for the surgery
  • Other individuals, as advised by the medical professionals

Even if you do not fit in any of these categories, we recommend you consulting your doctor before Cissus Quadrangularis supplementation because health safety comes first!


  1. Development and Validation of a Simple Isocratic HPLC Method for Simultaneous Estimation of Phytosterols in Cissus quadrangularis.
  2. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet.
  3. Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells.
  4. Determination of marker constituents from Cissus quadrangularis Linn. and their quantitation by HPTLC and HPLC.
  5. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats.
  6. Anti-osteoporotic constituents from Indian medicinal plants.
  7. Constituents of Cissus quadrangularis.
  8. Estrogenic activity of friedelin rich fraction (IND-HE) separated from Cissus quadrangularis and its effect on female sexual function.
  9. Mineral and biochemical analysis of various parts of cissus quadrangularis linn.
  10. CNS activity of aqueous extract of root of Cissus quadrangularis Linn. (Vitaceae).
  11. Safety assessment of Cissus quadrangularis extract (CQR-300): subchronic toxicity and mutagenicity studies.
  12. Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya).
  13. Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya).
  14. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study.
  15. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.

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