Cissus Quadrangularis is a plant popularly used as an herbal medicine across India, Asia, and Africa. Traditionally used in Ayurvedic and African medicine, it has worked wonders for treating female-related health conditions, such as low libido, menopause, and menstrual disorders and speeding up the bone healing process in case of fractures. Today, people widely use it for its pain relieving properties, anti-ulcer properties, and anti-hemorrhoid properties.
Moreover, in recent times, people are using Cissus Quadrangularis as a workout supplement to improve their body composition and help in bone and muscle recovery. Recent studies suggest that it may also prove beneficial in treating Western disorders, such as obesity and metabolic disorders, and in promoting healthy weight loss.
Today, people use this natural plant-based dietary supplement for its anti-inflammatory, anti-cancer, and immune system supporting benefits. Users also find it highly beneficial to aid weight loss, alleviate pain, improve cardiovascular health, and enhance athletic performance. Bodybuilders in particular, take Cissus Quadrangularis supplement as a legal alternative to steroids.
Also known as Vitis Quadrangularis, Cissus Quadrangularis is a creeping shrub that has a thick quadrangular fleshy stem. This plant belongs to the grape family and usually reaches a height of 1.5 m.
While traditional medicine uses only the stem, leaf, and root extracts, people in some parts of the world use the whole plant for treating various health conditions.
The traditional name of Cissus Quadrangularis is ‘Harjor’ or ‘Bone Setter’, as it joins the bones.
As per the phytochemical analysis of Cissus Quadrangularis, it contains high amounts of absorbic acid or vitamin C, anabolic steroidal substances, calcium, and carotene. Its stem contains two asymmetric tetracyclic triterpenoids that may have anti-cancer properties, two steroidal principles, beta-sitosterol, gamma-amyrone, gamma-amyrin, and some bioactive compounds, including flavonoids, vitamins, and minerals.
The presence of these diversified components explains why Cissus Quadrangularis supplement may exhibit a variety of pharmacological properties.
- It helps the muscles relax and acts as a sedative.
- Helps in reducing pain and monitoring joint health.
- Helps in weight loss and recovery from work-out.
Here are some common benefits of Cissus Quadrangularis.
1. Supports vasodilation
Cissus Quadrangularis acts as a vasodilator of the endothelium of the heart and blood vessels. This enhances the process of nutrient delivery through the bloodstream and helps in treating various health conditions on different levels.
A dose no more than 30 mg per kg of body weight is enough to induce generalized vasodilation within 30 minutes.
2. Promotes heart health
Taking a Cissus Quadrangularis supplement lowers the LDL i.e. unhealthy and overall cholesterol levels. By reducing the bad cholesterol levels in the body, it serves to protect your cardiovascular system from an excess strain, heart attacks, strokes, atherosclerosis, and high blood pressure levels.
It also reduces the triglyceride counts and increases the level of HDL i.e. healthy cholesterol. In addition to this, it changes the lipid profiles in plasma and slows down the process of blood-lipid peroxidation. All these effects of Cissus Quadrangularis seem to reduce the risk of developing heart disease and lower the mortality rates.
3. Improves immunity
Cissus Quadrangularis has powerful antioxidant properties.
Research shows that it serves to shield the phospholipid bilayers against the free radicals and thus, protecting the structure of cellular membranes. This is how Cissus Quadrangularis helps protect every living cell from the possible destruction caused by radical oxygen.
The high content of absorbic acid in Cissus Quadrangularis provides your body with an extra defensive shield against pathogens and other foreign substances. In addition to this, absorbic acid or vitamin C promotes the production of white blood cells to combat illnesses and infections, and hence, improves overall health.
4. Strengthens the bones and the skeletal system
Studies show that Cissus Quadrangularis has reduced pain and swelling in jaw fracture injuries in human patients.
One study found that Cissus Quadrangularis supplement increased the levels of calcium and phosphorus in patients with facial fractures to help speed up the process of healing.
Another study revealed that Cissus Quadrangularis provided relief against the joint pain in healthy men.
Cissus Quadrangularis is a powerful plant that promotes the growth and repair of bones and prevents the bone matter in the body from degrading. It boosts collagen production, reduces joint pain, and improves the range of motion of joints.
Research reveals that Cissus Quadrangularis stimulates the production of osteoblasts, the cells that are responsible for the growth of bones. This supplement also proves to be an excellent herbal remedy for people who have recently had a bone fracture to skyrocket their healing process.
5. Promotes weight loss
Cissus Quadrangularis supplementation shows amazing weight loss benefits.
One study shows that 300 mg of Cissus Quadrangularis extract may help lose weight and improve the levels of serotonin in overweight patients.
Furthermore, in yet another study, researchers found that the patients who received Cissus Quadrangularis supplement experienced a significant reduction in the levels of their blood glucose, triglycerides, cholesterol, and weight.
Hence, if you want to get rid of those extra pounds, consider taking Cissus Quadrangularis supplement in addition to following a healthy dietary lifestyle and exercise regimen. This supplement will work like a charm to boost your weight loss efforts by suppressing your appetite and stimulating your metabolism to burn fat faster and use nutrients efficiently.
6. Reduces inflammation
Some of the organic compounds found in Cissus Quadrangularis have powerful anti-inflammatory properties that help with swelling and irritation in the body.
Research indicates that this supplement plays an important role in reducing or treating the symptoms of hemorrhoids. Cissus Quadrangularis supplements seem to relieve inflammation in the affected area, providing comfort to the patients.
7. Helps with respiratory disorders
When it comes to respiratory disorders like asthma, Cissus Quadrangularis exhibits similar effects to steroids and helps in preventing asthma attacks or reducing their severity.
8. Prevents diabetes
One of the most beneficial effects of Cissus Quadrangularis supplement in the human body is the reduction in blood sugar levels. This supplement controls the release of blood sugar from the foods that you eat and ensures that the levels of glucose and insulin remain optimal in the blood.
In addition to this, the weight loss promoting effects of this supplement also help reduce the risk of type-II diabetes, as obesity and diabetes are linked together.
9. Promotes wound healing and quick recovery
Vitamin C is one of the major components of Cissus Quadrangularis, which is responsible for the building of muscle tissue, arteries, and blood vessels.
Cissus Quadrangularis supplementation serves to increase the levels of vitamin C in the body and thus, help in growth and repair of the muscles and tissues, speeding up wound healing and ensuring quick recovery from injuries and illnesses.
10. Helps with dental care
In addition to promoting your bone health, Cissus Quadrangularis also helps with dental care.
Studies show that people who take Cissus Quadrangularis supplements tend to have a better oral health.
11. Relieves menstrual cramps
Menstruation brings some serious cramps, bloating, mood swings, and hormonal imbalances with it.
Studies show that taking Cissus Quadrangularis supplement during menstruation may help relieve cramps and discomfort, making it a highly popular herbal remedy amongst women.
The right dosage of Cissus Quadrangularis supplement depends on what you are using it for.
If you want to lose weight or achieve body fitness, you should take 600 to 1000 mg of the supplement as per the general dosage recommendation. You should consider dividing this dosage into two smaller ones for a day.
We would recommend you to start with a lower dose and see how well your body reacts to and tolerates it. You can later increase your dosage gradually over time. The best way to go about this is to take Cissus Quadrangularis supplement 30 minutes before eating a meal. This will not only help you control your appetite but also manage the amount of fat and sugar that get accumulated in your body.
Furthermore, if you have fractured a bone or torn a tendon, you should take about 2000 mg of Cissus Quadrangularis a day. You may consume the 500 to 800 mg capsules 2-3 times every day.
In general, Cissus Quadrangularis is safe and the human body tolerates it quite well.
Many athletes and self-healers use this supplement to boost physical performance, lose weight, and promote overall wellness. Several physicians also recommend its use for treating a number of health issues.
There are only a few side effects of Cissus Quadrangularis – and they are all very rare, mild in nature, and temporary. Research proves that it is generally safe for human supplementation and serves as a natural, side-effect-free healing agent. The Natural Medicines database considers this supplement as possibly safe given the users take it orally and appropriately.
In some rare cases, Cissus Quadrangularis may produce some side effects, including:
- A headache
These side effects, however, are not only minor but also tend to go away on their own with time. The key to ensuring a safe Cissus Quadrangularis supplementation experience is to take the right dosage amount and not go overboard. In case these side effects do not get better over time or get worse, you should consider consulting a doctor or a medical health professional.
As far as the long-term usage of Cissus Quadrangularis is concerned, people belonging to different cultures in Asia and Africa have been using this supplement since before the Middle Ages.
In India, Thailand, Sri Lanka, and other countries of the world, people still use it as a common medical agent for treating a wide range of health problems.
Since Cissus Quadrangularis is a natural product that does not produce many side effects, people generally believe that its supplementation is safe for everyone. This, however, may not necessarily be true.
There are certain groups that should avoid supplementing Cissus Quadrangularis, including:
1. Pregnant and breastfeeding women
Since there is not enough clinical evidence supporting the safety of Cissus Quadrangularis supplement during pregnancy and breastfeeding, women who fall into these categories should avoid its use to stay on the safe side. In case they still want to take this supplement, they should not do so without talking to their doctor first.
2. Diabetic patients
Cissus Quadrangularis supplement may reduce the blood sugar levels in the body. If you have diabetes, taking this supplement in combination with diabetes medications might lower your blood sugar level to a dangerous extent. Therefore, you should not use this supplement without receiving a go-ahead sign from your doctor. Moreover, when you start its supplementation along with taking your diabetes medications, you should consider keeping your blood sugar levels in check and watch out for signs of low blood sugar (hypoglycemia).
3. People who have recently had a surgery
Cissus Quadrangularis may lower the blood sugar levels and interfere with blood sugar control both during and after a surgery. if you have a scheduled surgery coming up, consider stopping the use of this supplement at least two weeks before the scheduled day.
As with any of the herbal medications, you must first consult your doctor before beginning a Cissus Quadrangularis supplementation and changing your herbal supplement regimen. This supplement may interact with any possible medications that you may be taking and produce potential side effects. Some people may also show some minor symptoms when they are first exposed to the supplement.
The bottom line is that Cissus Quadrangularis supplement is completely safe and risk-free for use but you should still take it after consulting your doctor and follow the general dosage recommendation guide to ensure your health safety.
- Efficacy and Safety of Cissus quadrangularis L. in Clinical Use: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
- Beneficial Effect of Cissus quadrangularis Linn. on Osteopenia Associated with Streptozotocin-Induced Type 1 Diabetes Mellitus in Male Wistar Rats
- The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome
- Inhibition of Bone Loss by Cissus quadrangularis in Mice: A Preliminary Report
- Ketosteroid Standardized Cissus quadrangularis L. Extract and its Anabolic Activity: Time to Look Beyond Ketosteroid?
- The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress
- Clinical evaluation of Cissus quadrangularis as osteogenic agent in maxillofacial fracture: A pilot study
- Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling
- Safety assessment of Cissus quadrangularis extract (CQR-300): subchronic toxicity and mutagenicity studies.