Both Armodafinil (Nuvigil) and Modafinil (Provigil) are the kinds of drugs that help boost the brain activity. These drugs stimulate specific brain areas to make you feel more awake and alert.
Nuvigil and Provigil both treat sleep disorders such as narcolepsy, obstructive sleep apnea (OSA) and shift work disorder (SWD). These drugs are often mistaken to be the same. However, they aren’t similar at all. There are major differences between these two types of drugs.
Modafinil was originally developed in France by Lafon, also known as Cephalon. It was initially prescribed to cure narcolepsy. Doctors saw it as a potential treatment for insomnia. Therefore, it became widely popular. Furthermore, the drug also proved beneficial for cognition, focus, and productivity.
On the other hand, Armodafinil is the latest drug, produced in 2007 by the same company that developed Modafinil. Modafinil patent had run out. This is why the pharmaceutical company had to create a new drug that could provide similar benefits.
At first, both these drugs may appear to be similar. After all, they do share certain characteristics. However, Armodafinil has an entirely different chemical structure. Armodafinil is an optical isomer of Modafinil. This means that Modafinil contains the “R” and “S” enantiomers. On the other hand, Armodafinil contains only the “R” enantiomer. Due to this minor change, Nuvigil and Provigil have striking differences.
Modafinil has both R- and S- enantiomers in equal proportions in its structure. As a result, it helps maintain cognitive abilities and improves the mood of the user. However, various clinical studies conclude that the sole R-enantiomer is pharmacologically more active, stable, and longer-acting isomer. Since Armodafinil has only a single R enantiomer, it is more effective than Modafinil.
Modafinil commonly sold under the brand name – Provigil is a form of medication that treats drowsiness and sleepiness. It is a smart drug which is also known as a nootropic.
Modafinil has some notable characteristics that make this smart drug different from other kinds of drugs. First, Modafinil is not a stimulant. Instead, it is a eurogoic – a wakefulness-promoting agent. Unlike other typical drugs, Modafinil is not addictive either. This feature makes the smart drug extremely safe. In fact, research shows that Modafinil helps in curing addiction.
Clinical studies show that Modafinil increases your resistance to fatigue and significantly improves your mood. Although its mechanism of action is unclear, few studies show that it promotes alertness by stimulating your brain. A study reports that Modafinil may work by increasing the amount of dopamine – a chemical neurotransmitter that helps the nerves to communicate with each other – in the brain. It does so by lowering the absorption of dopamine into the nerves.
Modafinil is beneficial to those patients with narcolepsy, OSA, and SWD. Narcolepsy is a neurological disorder in which patients experience an excessive amount of daytime sleepiness. These sudden sleep attacks may occur at any time of the day. Obstructive Sleep Apnea is another type of sleep disorder that causes erroneous breathing during sleep. Shift Work Disorder causes excessive sleepiness while you are at work. Modafinil treats all these three health conditions which make it such an effective smart drug.
- It helps in keeping you awake for a longer period.
- Helps in boosting the mental strength and performance.
- It promotes focus and motivation.
Armodafinil is the R-enantiomer of the racemic modafinil. In 2007, FDA approved Armodafinil for the treatment of excessive daytime sleepiness. Like Modafinil, Armodafinil is also a medication that promotes wakefulness. It effectively treats irregular sleep patterns, associated with apnea, narcolepsy, and shift work sleep disorder.
Armodafinil is also a beneficial treatment for fatigue, linked to chronic illnesses such as cancer, Parkinson’s disease, HIV/AIDs, and various sclerosis. The main mechanism of this oral drug is also unknown. However, it works similarly like Modafinil. It functions by elevating the amount of dopamine in your brain.
Armodafinil increases or decreases the activity of enzymes in the liver that eliminate drugs. This activity may boost or diminish the effectiveness of some other drugs that you may have taken along with Armodafinil. If there is an increase in the level of a certain drug, there may be a rise in the toxicity level as well. Hence, you should be careful if you are taking any other drug along with Armodafinil. Some of the drugs that may reduce the effectiveness of Armodafinil include cyclosporine, ethinyl estradiol, midazolam, and triazolam.
The recommended dosage of Armodafinil is 150 or 250 mg daily. You should take it every morning, an hour before your work shift. This will help treat the sleep disorder. However, if you overdose the drug, immediately seek emergency attention.
Although the consumption of Armodafinil is safe, doctors recommend that one should avoid taking it with alcohol. If you forget to take a dose of Armodafinil, consume it as soon as you remember. However, avoid taking the medication if you are close to your bedtime.
Smart drugs – Nuvigil and Provigil have similar effects as the compounds are quite similar in nature. They are created from two identical stereoisomers of the same molecular structure, also known as enantiomers.
The consumption of these smart drugs will help you stay focused for a longer period of time. This, in turn, will increase your productivity level to a great extent. This is how these smart drugs improve brain power. However, as compared to Armodafinil, Modafinil is quite strong.
The effects of Armodafinil last longer than Modafinil. However, it primarily depends on the dosage level of Modafinil or Armodafinil. You will experience the effects of these pharmaceutical drugs for almost 8 to 15 hours. For most dosages, the impact is 10 to 12 hours.
Although there are striking similarities between these nootropics, there are major differences between the two as well. Various studies showed that the users of Armodafinil found it easier to sleep as compared to the users of Modafinil. With similar timing and dosage, users fell asleep 2 to 3 hours earlier after taking Armodafinil. It was also noticed that Armodafinil consumers were able to sleep more soundly without any disruption than those who took Modafinil.
As compared to Armodafinil, Modafinil seems to have slightly more side effects. You may suffer from stomach issues which you wouldn’t experience if you consume Armodafinil. To have similar effects, you will need to take Modafinil more than you will be required to take Armodafinil. For instance, in order to improve your brain function, you will need 200 mg of Modafinil while only 150 mg of Armodafinil.
To compare their tolerance level, Modafinil is a little bit addictive. Although none of these smart drugs are addictive, it is slightly easier to become more dependable on Modafinil than Armodafinil. Hence, it would be better to consume Armodafinil regularly as it has more positive benefits and fewer side effects.
Armodafinil is quite an effective nootropic, an upgraded version of Modafinil. Like other smart drugs, it boosts up your mental activeness. Research shows that Armodafinil improves mental efficiency without causing any form or confusion or irritation.
According to a study, Armodafinil inhibits the enzymes that may cause sleepiness in your body. This increases the level of extracellular dopamine in your brain. Additional cellular dopamine produces more dopamine to circulate around the neurons.
Armodafinil works in a particular subset of brain pathway where it regulates wakefulness and sleep. It works in three common ways. It acts as wakefulness and activeness stimulator, activeness and focus booster, and the quality booster of our mental performance.
Smart pills are normally known for energy boosting quality. Armodafinil works in a similar way. This is how it helps its user to stay active and awake especially during working hours. Another way the smart pills improve your mental activity is by the inhibition of fatigue and depression.
Often, these two factors are the sole reason for your poor performance. If you are suffering from a severe form of depression, you may miss out on your sleep. This may turn you into an insomniac. You will feel tired most of the day and it wouldn’t be easier for you to concentrate on your work. Lower concentration level may affect the quality of your work. However, the intake of Armodafinil can help cure depression and stress levels in your body. In this way, you will feel mentally active for longer hours.
In order to improve activeness and brain power, it is necessary that you take Armodafinil in a prescribed manner. Doctors suggest that users must take one smart pill in the morning before their work shift with or without food. Avoid engaging in any performance activity after the consumption of the pill as it may make you feel drowsy.
Modafinil offers various brain-boosting benefits. For many, the greatest benefit of Modafinil is promoting wakefulness. In other words, the smart drug allows its users to stay awake for a longer period of time. The consumer doesn’t find the need to sleep for minimum 12 hours.
In addition to promoting wakefulness, Modafinil also improves the focus of its user. Mundane tasks that appear to be impossible are easily done after the intake of the smart drug. An improved focus also increases the productivity level.
The combination of increased wakefulness and focus results in an improved cognitive function. It means that there is more room for extra productivity. The elevated cognition also allows the user to finish off complex tasks quickly. Modafinil also helps to enhance the quality of your mood. The Modafinil user finds tedious tasks enjoyable and easy to do.
Armodafinil treats multiple sleep disorders. One of them is narcolepsy that causes excessive daytime sleepiness. In one study, some patients consumed a placebo while others took Armodafinil. It was concluded that patients who took Armodafinil had an improved pattern of sleep as compared to those who took a placebo.
Armodafinil also helps cure shift work sleep disorder which is a condition observed among those who have a work schedule that forces them to stay awake at night while sleep during the daytime. A study showed that patients with shift work sleep disorder felt less sleepy during their nighttime work shift. This result was tested with the help of the Epworth Sleepiness Scale.
Armodafinil also cures obstructive sleep apnea syndrome that affects breathing during sleep. A study concluded that Armodafinil helps its users sleep peacefully without suffering from any breathing problems.
Armodafinil also boosts the brain. If you are suffering from brain fog, Armodafinil could be extremely useful for your condition. Armodafinil significantly improves concentration and focus. This, in turn, enhances the cognitive ability of Armodafinil users. People who use this drug reported that they experienced an enhanced reasoning ability. An improved mood and a higher level of self-esteem and motivation are all the added benefits.
Modafinil and Armodafinil are two smart drugs that provide instant real relief to patients who suffer from sleep disorders like narcolepsy, obstructive sleep apnea or shift work sleep disorder. The pills help normalize the sleep pattern.
They also act as a wakefulness agent which allows the consumers to stay awake for a longer period of time. In this aspect, it works like a dose of caffeine that charges up the user. However, unlike caffeine, they do not cause jitters, nervousness, or increase/ decrease your blood pressure or pulse rate. The user is able to work attentively without feeling any form of fatigue.
Modafinil and Armodafinil promote an intense feeling of energy and wakefulness. Reviews from multiple reports state that the drugs improve the focus to a considerable level. With the help of intense focus, the consumer of these smart drugs is able to think more profoundly. Hectic tasks that demand more of our energy are easily done without any problem. A highly focused brain helps the user to make good use of his mental capabilities. The use of smart drugs not only improves the memory but also heightens the retention level.
- Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies.
- Ready for takeoff? A critical review of armodafinil and modafinil for the treatment of sleepiness associated with jet lag
- Armodafinil versus Modafinil in Patients of Excessive Sleepiness Associated with Shift Work Sleep Disorder: A Randomized Double Blind Multicentric Clinical Trial
- Armodafinil in the treatment of excessive sleepiness